Thiamine and copper

[LAJ12345]

I was reading a web page about chronic fatigue and came across this:

OCTOBER 4, 2016, 12:20 AM

The basic idea is that there are two forms of copper, bioavailable and bio-unavailable. people that are copper toxic usually have high bio unavailable copper and low bioavailable. In the past, the only way for copper to be bioavailable was for it to be attached to known transporters like ceruloplasmin. Now Mitosynergy makes a Copper supplement that is attached to niacin which in theory means that it can enter cells through the niacin pathway without depending on ceruloplasmin. Many people believe that providing bioavailable copper to the cells restore it’s the health they need to detoxify the bio unavailable copper.

So I looked up copper and Parkinson’s and found this:

hindawi.com/journals/omcl/2...

V I am wondering if that is one of the ways thiamine helps? This article discusses the interaction of copper and iron in the brain. Pd patients have reduced copper, increased iron. Too much iron is a problem and the copper helps regulate it. Might explain why reducing red meat is also recommended?

This is interesting too, but more about fatigue which seems common:

howirecovered.com/my-story/

This is about Wilson’s disease which is a genetic condition where too much copper builds up in the brain. Thiamine can help by offsetting the effects of glucose and excess copper and can help protect neurons and prevent mitochondrial stress. Interesting.

Too much iron is a bad thing:

lifeextension.com/Magazine/...

academic.oup.com/brain/arti...

Interesting mentions doxycline chelates iron, aac.asm.org/content/56/7/37..., and I have read doxycycline improves symptoms. Perhaps that is because it is removing iron?

[LAJ12345]

Thank you. I will read it. This is my husbands worst symptom so far so hopefully thiamine will help!

[LAJ12345]

Hi, I have written to him and he isn’t replying. Hubby has atypical PD and he asked what kind and I said they don’t know as he hasn’t been to the specialist yet and he hasn’t replied. I tried again just in case he misplaced my email but still no reply. I do wonder if it because he isn’t on other medication having not seen a specialist. Does the b1 need levadopa to work or can it work with no other drugs? We now have been to the specialist and he has a sinamet prescription but he doesn’t really want to take it unless it is critical before he has tried natural remedies. Has doesn’t have any shaking etc just fatigue, hands that stop working after use and apathy.