Thiamine HCL and Mannitol concern - Cure Parkinson's

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Thiamine HCL and Mannitol concern

ConnieD profile image
31 Replies

I knew that Mannitol was a diuretic but was unaware that Thiamine HCl was one as well until I read some recent posts here. I remember many months ago when mannitol was discussed on HU on a regular basis someone mentioning to be cautious on your dosage because being a diuretic the results could be catastrophic if you took too much. Just wondering if this should be cause for concern for those using both. Should you only take one or the other or lower your dose of both. Should this be taken into consideration?

A bit confused thanks for any replies

31 Replies
park_bear profile image
park_bear

Mannitol is used in IV form for various serious medical conditions. For example, to prevent brain swelling as a response to injury the dosage is:

academic.oup.com/bjaed/arti...

"0.25–1.0 g/kg mannitol should be given by i.v. infusion over 20–30 min."

The dosage for Parkinson's is about half the lower value, but taken orally. Mannitol is poorly absorbed so the amount that actually makes it into the bloodstream is less.

I take both mannitol and thiamine and have not personally noticed a diuretic effect.

ConnieD profile image
ConnieD in reply to park_bear

Thanks Park Bear!

Juliegrace profile image
Juliegrace in reply to ConnieD

Me, too. What Park Bear said.

ConnieD profile image
ConnieD in reply to Juliegrace

Thanks JulieGrace!

Smittybear7 profile image
Smittybear7 in reply to park_bear

How much of each do you take and do you take them together ? Thanks

park_bear profile image
park_bear in reply to Smittybear7

I am not taking mannitol at this time. The most recent time I was taking I took about a gram three or four times a day, without regard for when I took thiamine.

Smittybear7 profile image
Smittybear7 in reply to park_bear

Why did you quit taking mannitol?Are you going to start it again? The dosage seems high. How much b1 do you take? Thanks for your help.

park_bear profile image
park_bear in reply to Smittybear7

The mannitol dosage I cited is about half of the dosage recommended for me by the clinicrowd website. I stopped because I was is possibly having some adverse effects but it could have been coincidental. I might try again sometime.

The correct thiamine dosage various greatly from one individual to another. Use the dosing instructions at highdosethiamine.org

ConnieD profile image
ConnieD in reply to park_bear

Thank you I stopped mannitol for awhile now it seemed after a couple years I was developing gastrointestinal issues. It may not have all been due to mannitol but everything did improve when I stopped taking it. I might try again too.

Smittybear7 profile image
Smittybear7 in reply to park_bear

It is hard to know what dosage b1 I should use since I am using supplements. I started at 1500mg and developed freezing that I didn't have before. I cut back to 1000mg and still having the freezing and constipation. Don't know if I should try to increase back to 1500 or not. Recent blood tests showed folate at 23.i was taken off all b12 which included the bcomplex so basically b1 is the only b vitamin I am taking Don't understand the reason as I am having symptoms of b12 deficiency.

park_bear profile image
park_bear in reply to Smittybear7

If the B-1 seems to be causing freezing I would definitely cut back. Some people seem to do best on much smaller doses then you are taking. Also, B-1 does not remedy everybody's constipation.

What are your B12 levels?

Sally Pacholok on B12, well worth a listen:

youtube.com/watch?v=5MKLdo-...

Smittybear7 profile image
Smittybear7 in reply to park_bear

Thanks for sharing the information on b12.i definitely will get tested. My question to my nutritionist is why did you take me off b12 for 6 weeks when I had a reading of 23. For folate. I definitely have signs of b12. Deficiency..my pcp did not include b12 on my last bloodwork. I appreciate your information. Thanks again The video was very interesting and helpful.

park_bear profile image
park_bear in reply to Smittybear7

Excessive folate is definitely not a good thing. Not complicated – If your level is too high the remedy is to stop supplementing the folate. I presented important information here:

Folate Supplementation Carcinogenic

tinyurl.com/ycdrz5lj

Smittybear7 profile image
Smittybear7 in reply to park_bear

Why would I have been told to cut b12 ? How do you cut folate and how often should I have my blood checked?folate is in a lot of supplements and foods. Is 23 an extremely high number for folate or is it just a little above the acceptable range.?

park_bear profile image
park_bear in reply to Smittybear7

Dietary folate is not a problem but supplementation is. I wrote about what I did to reduce my folate supplementation at the link.

There are different units of measurement for folate levels - μg/L or nmol/L.. To understand the meaning of your number the measurement unit is needed.

Smittybear7 profile image
Smittybear7 in reply to park_bear

Thanks! hope you are doing well what is the link?

Smittybear7 profile image
Smittybear7 in reply to Smittybear7

I found the link. So you shouldn't take any folate.????

park_bear profile image
park_bear in reply to Smittybear7

Correct, unless testing shows it is warranted.

Kia17 profile image
Kia17

No side effects so far. Taking both.

ConnieD profile image
ConnieD in reply to Kia17

Thanks Kia I feel reassured!!😊

lempa_nik profile image
lempa_nik

Why is the diuretic effect "catastrophic"? If not too extreme, it just means that a person needs to pee more often. I think the laxative effect, including possible loose stools and diarrhea, would be more awkward. But an average-size adult who takes less than 20g/day, should avoid the latter problem.

ConnieD profile image
ConnieD in reply to lempa_nik

I don’t remember who posted it but the word stuck in my mind it was about how if you take too much mannitol what it does to the intestines . I remember being concerned I was taking the proper dose because of it. It definitely made me worried about taking too much. Thanks for your response dumpekin!

Skme profile image
Skme

I’ve been taking bath and have not had any side effects.

134A profile image
134A

I am also taking both with no problem

chartist profile image
chartist

Connie,

Things that act as a diuretic can tend to deplete magnesium, potassium and zinc, but how strong of a diuretic action is important in making that determination. From member reports so far, this combination does not seem to have a strong diuretic action, but nothing wrong with asking your doctor to test your magnesium, potassium and zinc levels at visits or just before visits to be safe.

Art

ConnieD profile image
ConnieD in reply to chartist

Thank you Art!!😊

kaypeeoh profile image
kaypeeoh

I'm aware that gastric enzymes can affect absorption of most medications. So I've ordered sublingual drops which are absorbed bypassing the stomach. I just noticed B1 is available as as an animal drug. I don't mind experimenting so if the drops are a bust I'll order the B1 injectable.

House2 profile image
House2

Diuretics can lower blood pressure. This can make light headedness worse.

LAJ12345 profile image
LAJ12345

My husband takes the tbs of mannitol and 1000mg b1 or 1500mg alternating days. He finds if he takes the 1500 every day he needs to pee more. 1000 and he doesn’t but symptoms start to worsen if on just 1000. His sweet spot is in between I think. If you take too much your body flushes it out by making you pee more. Makes sense!

LeharLover62 profile image
LeharLover62

So I’m not sure about this, still experimenting, but I think mannitol is starting to exacerbate my husbands orthostatic hypotension, and when we added high dose thiamine back into the mix it got better. I’m really curious to see what others are experiencing.

Fumaniron profile image
Fumaniron

1 take 1 heaping tablespoon mannitol a day, and 2 grams thiamine HCL twice a day. Been doing for a couple of years now. working well for me

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