Parkinson's Movement
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Madopar vs Sinemet (& mucuna)

Neuro just put my husband on Madopar (one of the side effects being nausea...for some reason he didn't prescribe Sinemet) We were hoping to supplement with mucuna once his body gets used to the drug. My understanding is that mucuna needs the carbidopa in Sinemet to be able to cross the BBB. Does the same apply to Madopar if it doesn't have carbidopa? Any information would be greatly appreciated as neither of us are coping very well with his severe depression and sleepless nights (we're both very thin and losing weight, no appetite)

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Madopar contains benserazide which is equivalent to carbidopa. If the Madopar does not agree with him perhaps the Sinemet would be better.

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Thank you so much for responding. There is so much talk about carbidopa and I couldn't find much on benserazide. You've set my mind at ease.

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The herb valerian root can help with sleep. (note - has bad smell before you get it down)

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Thanks again, you're a wealth of knowledge! I'll find out about that. We've been using melatonin drops and it has been helpful, but maybe not as effective as it was 2 years ago? Lately it's the trips to the bathroom (between 5 and 7 per night) that seem to come on urgently in the wee small hours of the morning (pardon the pun). Then when awake the anxiety kicks in. Hopefully the antidepressants that he slowly started on 3 weeks ago will start to take effect soon.

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Probably why the Dr didn't prescribe sinemet because of antidepressants.

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Hmmm maybe. Since found out that our neuro hasn't been prescribing Sinemet to any of the people in our support group.

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I avoid drinking fluid for 2 hours before bed except as absolutely necessary to avoid those nighttime trips.

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Thanks. We have tried that but to no avail. We are now wondering if maybe it's connected with the depression/anxiety?

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My husband has found the Super Healthy Prostate by Dr. David Williams extremely helpful for not having to get up nights. Before that I used to buy all kinds of brands of Saw Palmetto and herbal combinations and nothing worked. My sister told me about this and I am so glad to have found something that works. You don't have to wait weeks either. It starts working right away . I do hope you husband is on a good b-complex like Jigsaw or some other bio-available kind. It might be helpful for the depression. 5-HPT and L-tryptophan can be for good for sleep and depression. It helped my husband but for some reason he is sleeping so much better then he used to and no longer needs it.

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Thanks for your reply. Unfortunately they won't ship to Australia. Thank you for the reminder on all that other good info too!!

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Has you Husband had his prostate checked out by GP & scanned? My Husband was in the same position as you describe, forever up to urinate during night but little output - sleep deprivation caused anxiety, exhaustion, low mood, weight loss & feeling wretched. Pills didn't reduce the overlarge prostate and he's worn a catheter for 8 months. But recent surgery for prostate reduction / realignment means bladder control is 100% now. Additionally, his PD symptoms are improving too, with many fewer 'off' times each day, and stronger 'on' periods. He takes Madopar (instant) every 6 hours during day, 1 x CR Madopar at night plus 1 x Primapexil in the morning - with no adverse effects at all.

He takes no supplement - no additional 'anything' - simply eats a balanced healthy diet, enjoys a glass of cider most evening - and the prescribed meds: -

I do hope your Husband can find some relief - for I know how exhausted you both must be.

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Thanks for your detailed reply! He has had his prostate checked and they tell us it is within the scale for someone his age but I must admit it does sound exactly as you described your husband.

What we are thinking at this stage is that the antidepressants have started to work as we had thought maybe the frequent urination could have been from the extreme anxiety. The last 3 nights he has only woken once or twice each night...sleep deprivation has horrible consequences. Also he is a lot brighter within himself, not so withdrawn with the blank expressionless face.

You're right, we have both been totally exhausted. (Your poor husband having a catheter in for 8 months!)

So pleased for you that it is all sorted.

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I have been taking mucuna for about 8 months and that's all I take. I am now in my 9th year of Parkinson's. I believe the issue with crossing the blood-brain barrier is you must not have protein when you take the mucuna until it kicks in. Unfortunately I work so I save most of my proteins for in between and mainly at night when I'm home. I used to take Carbidopa levodopa until I found mucuna I take 1/2 teaspoon dos and it lasts me 4 hours almost every time.

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Really? You take mucuna and nothing else? That's really interesting. How long were you taking the carbidopa levodopa for before starting the mucuna? Where do you get it from, and do you know what % levadopa it has in it? Also is it organic?

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Hi, I was taking Carbidopa levodopa for approximately 8 months. I went quite a while before I felt I needed medicine. That is not the case anymore, unfortunately. Nutrivitashop.com is where I buy it. They claim it is 99.6% pure pharmaceutical grade organically grown from India although it is not certified. There are times when I get a little nauseous but it's not for long periods usually no more than a half hour. My best most effective dos is in the morning with coffee but I use almond milk or non-dairy milks that don't have protein. During the day I mix it with a half a teaspoon of vitamin C that I bought from the same place in bulk form. I buy 250 g bags for $62 it last at least 3 to 4 months. I used anywhere from 1 to three times a day depending if I'm working or not. When I'm home I try not to take it so as I don't build up a resistance to it. When I started I only took one eighth of a teaspoon just to see how I would respond within a few days I was doing 3/8. I increased the dose to half a teaspoon and it gets me rough before hours sometimes five and then the party is over. LOL if you have any other questions I'll be more than happy to help you! By the way you don't need to buy a 250 gram bag they have much smaller versions for a lot less money.

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Thanks for all that information! So much to work out, but you've made it easy. When you stopped the carb/levo, did you stop cold turkey, or did you wean off before starting the mucuna, or introduce the mucuna before reducing the carb/levo? Sorry about all these questions.

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I was taking three or four 100 mg of Cl a day. I weaned off over a one week period then I started the mucuna. I personally started with two eighths of a teaspoon. Then I had done 3/8 for a couple of weeks until I realized half a teaspoon AKA 4/8 was the right dose for me. Meaning I got roughly 4 hours of up time which was around what I was getting from the CL. Initially I was so concerned with trying to dose the same amount of mucuna that equaled 100 mg of Cl but I soon realized it wasn't enough and doesn't really work the same way. In my research I found there is something in green tea that's helpful getting the mucuna to cross the BBB but I had zero love affair with green tea. The person who recommended mucuna to me had great results mixing it in coffee. I find coffee works for me as well. It is critical that you do not mix it with milk or any protein because it won't work as well. It takes roughly 30 minutes or so for the mucuna to kick in after that time you can eat if you're not too nauseous LOL. Try to eat in between your doses. Good luck and let me know how you make out! P.S. As I mentioned before I mix vitamin C A half a teaspoon as well in my other doses because I can't do much more than a cup of coffee a day.

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I've ordered the mucuna and waiting for it to arrive. Because we've been on a roller coaster trying to deal with the severe depression AND the Parkinson's (with the depression being the most debilitating at present!) we've decided to wait until all settles down (unfortunately with doctor's drugs) then we'll try and work out the correct dosage for my husband with the mucuna. He's now seeing a psychiatrist who is very knowledgeable with anti-depressants and Parkinson's. For the first time I feel like I'm not doing it on my own, even though I feel I have failed in my attempt to do this whole thing naturally. But I also know when he is stabilized we can then introduce the mucuna and cut back on the madopar. Thank you for all those ideas on how to take it. I will definitely keep you posted.

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Good luck with everything!

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Hi fellow Aussie! did you have any luck with finding anyone who does Marty Hinz protocol in Oz? My husband has just been put on Madopar too and 10 days in there is no improvement . Have you tried Mucuna yet? I d love to find someone in Australia who understands Mucuna a enough to help us get the dosage right.

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