Mucuna Prereins: Hi I was diagnosed... - Parkinson's Movement

Parkinson's Movement
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Mucuna Prereins

Lmji
Lmji
26 Replies

Hi I was diagnosed with PD seven years ago my neurologist has me on Sinemet100 mg tablet 3 to 4 times a day, sifrol er x 1 and Azilect x 1. Last week I started using mucuna prereins (MP) It's much more effective and lasts longer. I got my m/p from China and its 98% l dopa.

I've stopped taking sinemet, azilect and Sifrol and now going through the withdrawals.

My question is this I'm taking 1/4 teaspoon of MP compared to the 100 mg tablet that my neurologist prescribed.

Is this too much? Can someone please offer some advice as I can't ask my neurologist he won't be interested

Thanks

26 Replies
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Dap1948

I recommend the book "Mucuna versus Parkinson's" by Maldonado. It gives a lot of good advice. 98% ldopa is rather high. 15% is suggested because it allows for all the other good things in mucuna to be in a dose. But read the book. It's got products and doses and where to source them as well as advice on swapping from synthetic to natural.

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Lmji
Lmji
in reply to Dap1948

Thanks

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Juliegrace

Purchase a jeweler's or supplement scale that can measure in milligrams. I weighed 98% pure MP derived L-dopa and 1/64 of a teaspoon was approximately 40mg. Yours may weigh differently, but for mine 1/4 teaspoon would be over 600mg. (I think that's right, but it's late.)

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Lmji
Lmji
in reply to Juliegrace

Thanks

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Harleybob08

I am on MP 98% as part of my Amino Acid regime. This concentration must be treated with caution and should only be dosed via a jewellers scales.

I have no experience of Pharma drugs, but would strongly recommend being clear of them if using my advice.

You will probably need to take 5HTP to combat the nausea which will arise. In the same way as Sinimet uses Carbidopa .

The daily dose of 98% MP (LDopa) should be in the range 2G - 7G. Best to start low and rise slowly. Do not go over 7G.

Same with the 5HTP. Start low (1-tab) and rise until the nausea goes. 5 tab max.

Please understand that this is a case of the blind leading the blind, but we're all in the same boat. Best is to go with a doc. Mine is Ron Cargioli in Indiana.

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Lmji
Lmji
in reply to Harleybob08

Thank you so much at last someone I can communicate with. I've been without sleep for three days now because of the withdrawals from sifrol and azilect. I've decided to go back to them but not to sinemet. I'm desperate for sleep. I live in Melbourne Australia and its 130 am. This is my third night the heart palpitations woke me up. I measured 1/4 teaspoon it weighs about 800 mg. I take a total of about 4.8 grams. I spoke to my dr this afternoon but he couldn't offer any advice.

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S70AWD
S70AWD
in reply to Harleybob08

What is SHTP?

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Lmji
Lmji
in reply to S70AWD

That should be 5 HTP

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Harleybob08
Harleybob08
in reply to S70AWD
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Catlou

Do you feel better on MP

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Lmji
Lmji
in reply to Catlou

Yes it takes about 20 minutes to kick in and lasts longer than sinemet.

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Beckey
Beckey
in reply to Lmji

That's been my experience too! With sinemet, I get this horrible rigidity and contortion in my right foot. With MP, I get a slight reaction along those lines but nowhere near as bad. It just seems gentler over all, and as you say, lasts longer.

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Catlou
Catlou
in reply to Beckey

So how is mucana going and what do you take, how much,,how often and what else? I seriously want to stop sinereti.

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Lmji
Lmji
in reply to Catlou

So far good. I take about 1/8th teaspoon 1st thing in the morning with 1teaspoon of mannitol. Generally kicks in within 10 to 15 minutes and lasts about two to three hours. No where near the side effects of sinemet. Only problem is that mucuna is in powder so ease of use sinemet is simple. I take between 3 to 4 doses a day.

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Lmji
Lmji
in reply to Catlou

Yes much better than sinemet

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MBAnderson

The supplement companies say their product is 98% (pure) but they don't say explicitly that is the amount of L-Dopa. I think that refers to the purity of the Mucuna Pruriens, not the % of which is L-Dopa. Usually the extraction ratio is 4:1 or 15 or 20% L-Dopa. Any one else figure this out?

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Harleybob08

nutrivitashop.com/search?ty...

Tend to disagree. Some are available with analysis sheet. Certainly works for me.

:-)

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Lmji
Lmji
in reply to Harleybob08

Can I ask how long have you been on MP for

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Harleybob08
Harleybob08
in reply to Lmji

18months

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Lmji
Lmji
in reply to Harleybob08

And are you having any side effects

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Harleybob08
Harleybob08
in reply to Lmji

Not as such. Picked up a wobbly head when I overdosed (9g/day), which is gradually easing.

It causes nausea (not bad) until in balance with 5 HTP, mostly I would rate it as free from side effects.

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MBAnderson

Thanks. I don't follow. Will you elaborate?

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Lmji
Lmji
in reply to MBAnderson

I took 1/4 teaspoon this morning at 736 it started to work within 20 minutes however it was too much and felt nauseous for about 20 minutes. But it kept me going for 4 hours So it must be pretty pure

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Joecola

Is anyone taking MP with L-Tyrozine?

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MBAnderson

Got my answer.

Hello no its pure l dopa derived from the Mucuna, its 99.6% pure l dopa.

Thank You,

Vincent Tian

NutriVitaShop.com

8 Rancho Circle

Lake Forest, Ca 92630

Tel: 949 232 2183

Fax: 949 232 2183

E-mail: vincent@nutrivitashop.com

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Lmji

Dear PD Battlers.

I found this article on mucuna which may interest some of us.

jnnp.bmj.com/content/75/12/...

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