New therapies

Dr. Robert Hauser has recently penned an outstanding paper reviewing all the new therapies in the Parkinson's disease pipeline. Dr. Hauser is professor at the NPF Center of Excellence at the University of South Florida in Tampa.

Here is the link to the article which is free access through pubmed: ncbi.nlm....pubmed/22035030

Int J Neurosci. 2011;121 Suppl 2:53-62.

Future Treatments for Parkinson's Disease: Surfing the PD Pipeline.

Hauser RA.

Departments of Neurology, Molecular Pharmacology and Physiology, College of Medicine , University of South Florida, Tampa, Florida USA.

ABSTRACT

Our current wish list for the treatment of Parkinson's disease (PD) includes therapies that will provide robust and sustained antiparkinsonian benefit through the day, ameliorate or prevent dyskinesia, and slow or prevent the progression of the disease. In this article, I review selected new therapies in clinical development for motor features or treatment complications of PD, and some that may slow disease progression.

These include

adenosine 2a (A2a) antagonists (istradefylline, preladenant, and SYN115), levodopa/carbidopa intestinal gel (LCIG),

IPX066-an extended-release formulation of carbidopa/levodopa,

XP21279-a sustained-release levodopa prodrug,

ND0611-a carbidopa subcutaneous patch,

safinamide-a mixed mechanism of action medication that may provide both MAO-B and glutamate inhibition,

PMY50028-an oral neurotrophic factor inducer,

antidyskinesia medications (AFQ056 and fipamezole), and

gene therapies (AAV2-neurturin and glutamic acid decarboxylase gene transfer).

Some of these therapies will never be proven efficacious and will not come to market while others may play a key role in the future treatment of PD.

PMID: 22035030 [PubMed - in process]

1 Reply

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  • thanks for all the informative posts. I remember your post from early January. None of us would chose this road but now at least we have our own little on line village where we can inform,, vent and challenge.

    Can you check the link on ths? I tried it several ways with no luck.

    Thanks.

    Jill

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