Just a short post to let you know I have completed my first round of Topotecan (3 doses) with a drop in CA 125 from 57 to 47. I know that a 10 point drop may not seem like much, but for me it is. The side effects have not been very bad either. And the BEST NEWS...my second grand daughter was born this week. I think it's time to plan a little adventure somewhere. Fondest regards to all.