What is the next procedure with a rising CA125 recurrence, except wait for it to get worse and then have comb chemo again?

[Indigo-Blue]

Diagnosed 3c sept 11 started on carboplatin and paclitaxel

Adverse reaction to paclitaxel continued on small dose of carbo

After total of 4 chemo debulked in May 12

2 more chemo of carbo

CT Aug 12 NED

Feb 13 CA125 rising prescribed letrozole 2.5 mg / day by onc CA125 plateaus then falls!

Dec 13 CA125 rising again

Present day still rising still taking letrozole

[Hidden]

Hi indigo-Blue,

Sorry you have a recurrence, I would think that because you have had a reaction to taxol that the next combination chemo would be Carboplatin and Gemcitabine as it is your first recurrence you would qualify for Avastin as well...so it might be worth asking your oncologist about your suitability for this... (Avastin hasn't been passed by NICE for third line chemo) so if you don't enquire about it now you would have missed the window of opportunity... saying this Avastin isn't suitable for everyone but no harm in asking....you could give the Ovacome helpline a ring tel [phone]

Best wishes love x G x

[Hidden]

Hi, it looks like the first line treatment worked quite well, the letrozole is similar to tamoxifen whereby it is given to slow things down and this seems to have worked. It would normaly be standard practice to repeat the 1st line after a decent spell of remission and thus keep the other options for later use if required. However the use of Avastin can only be administered as 1st or 2nd line treastment and therefore those who think this is a chance not to be missed then given with Carboplatin and Gemcitibine its worth asking. Its a difficult choice since you know carboplatin worked well the first time. Your oncologist should advise you on the options. Love Paul xx

[jt25741]

You can also ask about Abraxane instead of Taxol. Often the allergies are not related to the drug, but the other components in taxol that are related to drug delivery. Abraxane is the same basic drug, but often very tolerable. Worked great for my wife for a long time.

[drdu]

You don't say what your CA125 level is. Maybe the rise could be for other reasons? Are they considering another scan?

Eileen xx