I started Effexor XR 8 weeks ago at 37.5, after 2 weeks went to 75, then 2 weeks 112.5, then after 3 weeks 150. 150 for 1 week I experienced a spike in anxiety and rumination.. .I'm still going through it. I went down to 112.5 the past 2 days and am still majorly suffering the anxiety, rumination and depression. Hoping it'll calm down. I need to get past this. I'm so afraid I'll live like this forever.