RA for 25 years, on hydroxychloroquine at the moment. Have severe chronic neutropenia for over a year now. The rheumatologist wants to put me on one of the above drugs in the hope it will help with the neutropenia. Whether it will or not is uncertain, they are running out of options for me but said as things are i am walking a tightrope and at significant risk of severe infection. Already had neutropenic sepsis once. Cant tolerate neupogen which is the usual drug for neutropenia, it makes me so ill. Was on methotrexate about 20 years ago but came off it because it scared me. What decision do i make now. Could really do with some thoughts on this from people with more experience than me who have used these drugs. Rheumy said i could go on whichever i want to but cant say if it will improve my condition or make it worse! Catch 22.