Thank you all for your helpful input. There are SO many things that a rheumatologist can't tell you unless the, too, have the disease. I imagine they can't predict the side effects of the mtx because many folks seem to have different experiences. The mtx really affected my brain the first few weeks, but that has settled down. Then I ended up in cardiac unit of hospital for terrible pain that made me pass out, but was classified as gastrointestinal event. I blame the mtx. It is one day at a time for me, but you are all AWESOME in your willingness to share and help.