I have a chronic bladder condition and suffer with urinary tract infections from time to time. Several weeks ago I decided to opt out of starting enbrel and instead chose to go on methotrexate, the reason being that I was concerned about the cancer risk with the former. I think my rhematologist would have preferred me to go on enbrel as she was more concerned about my UTIs than the cancer risk, but was willing to go along with my mtx suggestion - I think the main reason for her mode of thought here is that enbrel exits the body more quickly than mtx thus enabling my immune system to fight an infection more quickly should I get a stubborn UTI.
Now after hearing David Cameron currently voicing his concerns about antibiotic resistant bugs I'm having second thoughts about going on enbrel. I was previously aware of the concerns about antibiotic resistant bugs and did take this into account when I chose to go on mtx, but something I completely forgot to think of at the time was that there are two types of antibiotic that you are advised not to take while on mtx. I can't recall one of them but trimethorporim (scuse spelling) is the other, which according to my GP, is the drug of choice for e. coli infections, which as luck would have it is the type of infection I usually get. I'm not aware of any antibiotics that you can't take with enbrel(?)
I am now thinking of phoning rheumy helpline in the morning to see about stopping mtx and starting enbrel as my rheumatologist did say that this option was still open for me should I change my mind in the future.
I'm still a little unsure about all this and maybe I'm unduly concerned, so would greatly appreciate some thoughts on what others would do in the same situation so I can make a more informed decision.
I should mention that I also take lefluomide and hydroxy with mtx.