I have been recently been diagnosed with PA and Mtx was mentioned but I am not on any meds yet. I have been reading the horror stories of people suffering with terrible nausea and stomach cramps etc. I am really scared about being put on this drug as it sounds like it could be an awful experience. Does everyone have this reaction when they take Mtx or is it that it just affects some people. I had a stomach operation a few years ago and my digestive system is just about ok but I do suffer with indigestion and constipation and I really would like to avoid any more complications. Any advice?