I was diagnosed three years ago with RA. Started on methetrexate, developed terrible mouth ulcers when i got to 8 pills a week. Started lefloridimide and lost hair. Then started a half dose (10 mg daily) of lefloridimide and 4 pills methetrexate weekly and that worked great on my RA symptoms without side effects for a year and a half. Then the mouth ulcers started back. At first just a few every weeks then several at a time all the time. I stopped the mtx amd started sulfrasalizine. After 5 weeks had terrible mouth ulcers. Worse then with the mtx. Rhumy now says we've tried all the orals and we have to go to biologics. I don't mind needles but a side effect if cancer sounds worse then mouth ulcers. Rhumy says that studies are now showing it's inconclusive if biologics cause an increase in lymphomas. What do you think? Any suggestions of other meds to talk to my rhumy about? Any experience with biologics? Other side effects of them?He's suggested humera or another popular one that i can't think of the name now. Please let me know your thoughts. I appreciate it.