From reading other posts I am like a lot of people , frustrated!!! I am just about to start on my 4th anti TNF (I failed on the first three) throughout the last three anti TNF'S topped up by methyl pred infusions I have been having flare ups every 7-10 days that last 3-4 days and mini flares every night . Is this normal or is it just a stage I am going through and will it improve? I don't see my rheumy for another three months but starting on Tocilimab on Wednesday. I am just about managing to hold down my job but if things don't improve soon I am not sure I will have it for much longer.