embarrassing question...

[lulul]

Since going onto mtx injections (20mg) I suffer from extreme diarrhoea from 3-4 hours after for about 3 days then it's gone again. This happens like clockwork after every injection. Is it normal??

[Hidden]

Sorry lulu but I've never suffered from this, infact I'm the opposite always constipated! I would certainly mention this to your GP or consultant.

Wish i could be of more help, good luck.

Mandy xx

[Hidden]

No not normal I wouldn't think! You will be losing valuable minerals. It sounds as though the injections might be too strong for you. It may settle as your body adjusts but perhaps something that needs an earlier solution such as a drop in dosage perhaps?

Of interest, my rheumy nurse explained yesterday that taken orally a 10mg dose may be worth as little as 5mg by the time it has gone through the gut. As everyone's absorption rate varies this is why it's such an inexact science; some do well on 10mg others need 25mg. The same 10mg injected into the bloodstream is the full value 10mg.

Hope you can get it sorted quickly,

Lyn x

[Hidden]

Hi Lulu - errr well yes this has been the case for me too. Only lasts for 24 hours then I am ok. But from what others say it coul be a problem, so might ask around either the RA nurse or gp next week. All my bloods are normal so I have not been worried about it....

Julie xx

[emandedmum]

This happens to me as well, not regularly but enough for it to be a real issue with the injections but it is a bit of a nuisance. Also usually happens in the middle of the night which isn't ideal! It seems to settle down then will flare up again, I did put it down to IBS as I'm sometimes the other way too but it could be the mtx. Mention it to your nurse or consultant next time you go and see them xx

[Hidden]

This happened for me too on the pills, however I'm now on the injection and it has reduced my sickness completly and my diaoreha a little but not completly just not as bad, I still have the tiredness feeling from it.

But as the others say always get symptons and side effects checked out.

You never know.

Take care

Julie x

[Hidden]

advice as above.severe diahorrea should be reported to rheum team/ gp

side effect profile posted full listed of side effects on another blog/ question somewere in answer to some elses query

[cathie]

I have very unpredictable guts since going on the various medications for RA and diabetes. Bloods are OK so I assume its just something I have to live with. When I go out I'm careful what I eat beforehand, and try to fix on nearby loos.

When I started methotrexate my RA consultant suggested I take it at night to minimise this effect, and so its only in the morning that this starts.

Unpleasant. XX