Nausea and MTX hangover

[Gilliancheche]

I've been injecting MTX for a couple of years now but have noticed the last couple of weeks I have suffered a lot of nausea through most of the week. I take folic acid 6 days. Also the day after injection I have felt really rough. Previously I had not been struggling like this. Could it be a new batch is somehow different? The packaging, brand and dosage are same as usual. Could my tolerance suddenly change?

[Brian1977]

I'm the same gillian take my injection on a Monday and I can't eat until Friday the sickness feeling is the worst and just feel run down all week

[Madmusiclover]

just my experience but the longer I took it the sicker I felt. Had to stop.

[Bootoo]

I've been the same recently and have been injecting for about 5 years , my doctor prescribed anti sickness tablets and they have been quite good ,speak to your GPS or rheumy team I'm sure they can help

[AgedCrone]

Have you been keeping up your fluid intake.? It really does help if you drink plenty of water…particularly the day before Mtx.

[Gilliancheche in reply to AgedCrone]

Thanks for that suggestion, I hadn't really given that much thought. I will make an effort to increase it especially on the day of injection. Somewhat irritating as I delayed my day a couple of weeks ago due to a cold and now inject on Friday and have a rough weekend in particular 🥺

[AgedCrone in reply to Gilliancheche]

Good luck…it really is a convenient drug to take & if only you can get it right you can lead a really good life. I was on 25mg for many years.

OK it did just stop working back in 2016 & I went on to Rtx which I think works so well because Mtx broke the back of it - if you see what I mean. Now I’m on just one infusion a year. OK a few niggles, but no horrendous flares. ..& life is very bearable.

[watcher56]

Me too! I had wondered if I had a bad batch especially as I coped ok on 25mg and am now just on 15 mg. About to start a new lot, see how that goes

[Gilliancheche in reply to watcher56]

I have previously coped on higher doses but I am wondering if the current batch of 15mg is suspect

[Jackie1947]

Going back a few years now I started off with Methotrexate tablets but that gave me mouth ulcers progressed onto injection but after a good year I had a bad reaction and taken off it. Seems I became intolerant to the drug.

[Leics]

I experienced the same thing but methotrexate stopped working for me after covid. The sickness just became intolerable and even though I gave it another 5 months I had to stop. I hope things improve for you but my GP did prescribe an anti sickness med but that wasn’t enough to help.

[Egpa]

Have you checked with your consultant that you don't need to lower your mtx injection. That's what happened to me even though I took folic acid 6 days a week. They lowered me from 25 to 20 when I was feeling unwell and sick. Seams to have done the trick. Good luck.

[linmar]

Sorry, I'm of no help. I've only had 10mg methotrexate tablets to compliment the Amgevita Injections. This combination works fantastic for me. I've been on this combination since 2011 and pain-free and no more fusing.

[hopegalore20]

Hi Gilliancheche, I can relate to what you are experiencing with self injection of Methotrexate. I was on this initially with the tablet format. Then switched to the injection pen.Methotrexate always made me feel awful. It did not help much with my condition. I was eventually weaned off and switched to Mycophenolate.

Speak advice from your Consultant or GP if you feel that this med is not helping you!

Good Luck x

[fred42]

I struggled with Methotrexate for many years, trying all sorts of different doses . My GP thought I had IBS and life was difficult with constant nausea and diarrhoea, eventually I gave up on the unequal struggle and with my consultants approval moved on to the biologic Cymzia. Since then I have been well and RA is well controlled.We are all different and I do get side effects from many medications. Hope you get sorted.

[Annie55]

I was fine on methotrexate for a number of years and then the sickness started and gradually lasted longer and longer. I was taken off it and doing okay until I had a bad flare up, now doing okay on jak inhibitors. I would speak to your rheumatology nurse to see what they think.

[Poshcards]

Was on 25 of Metho injections for years but 3 months ago I was so ill after injecting with nausea, diarrhea up to 12 times a day, that I requested to come of them , rang my consultant and she totally agreed. I now have the RA pain, but not the awful symptons x

[Curcubeu]

I experienced this and the solution was to lower my dose as the disease wasn't so active as before. I suggested it to the Dr and he agreed. If you haven't had a flare up or major issues for a good period of time ( doctor will ask you and decide), it may be your case too.Note: I felt the dose reduction for approx 2 weeks, until my body rebalanced again, it was like my symptoms exacerbated, the body needed to readjust from 25mg to the new 15 mg, but I settled down soon and here I am fine since. 🙂

So maybe it is worth giving it a try if you are in similar position.

All the best

Carmen xx

[Swanfull]

Hi feel for you. MTX sorted my pain out but had to suffer with side affects for two years, first tablet form then injections couldn’t tolerate either. Made me feel so Sick! Life was so miserable. Couldn’t stand it for any longer so spoke to my Rhuemo team and was changed to Benapali injections, it was a life saver. I still have flares but at least the dizziness, sickness and brain fog have gone 😩 hope you get sorted soon 🤗

[AgedCrone]

Do speak to your rheumy team…if you get any change in the efficacy of a treatment you have been on for a while.

It may be a common thing & they are just waiting for you to tell them It has happened to you!

[catwoman4]

I had same problem but just a for couple of days following the injection and couldn`t make plans to go out or do much at all, fortunately I had been well enough to have the dose lowered to 10mg and now coping well, just an occasional off day, hope you soon get sorted