I wonder is anyone can share their experience with me. I am on 20mg of methotrexate which I take in tablet form once per week and feel sick for about three days after, I have been advised by my consultant to split the dose into two lots of 10mg which has not really helped. My questions are in your experience do the injections make a difference and do you feel less sick and where do you have to inject yourself? I would be very grateful if anyone could offer me some advice. Thank you.