Mtx nausea increasing - normal?: Hi all - I am on my... - NRAS

NRAS

37,274 members46,139 posts

Mtx nausea increasing - normal?

seneca profile image
8 Replies

Hi all - I am on my sixth week of methotrexate 10mg. Felt absolutely fine for the first 2 weeks, but every week after that brought greater nausea. Feeling very sick now. It seems that most people have a decrease in nausea the longer they take mtx, or as they get accustomed to it? I'm taking 5mg folic acid on the other 6 days per week, and drinking loads of water.

Sorry if this seems like a trivial question, but here in South Africa they don't monitor us as closely as they do in the UK - after the initial pre-medication blood test, the next test is only scheduled for mid-July, after 9 rounds of mtx. Just worried, and needing reassurance that others have had similar nausea increase without adverse liver effects. Thanks in advance!

Written by
seneca profile image
seneca
To view profiles and participate in discussions please or .
Read more about...
8 Replies
helixhelix profile image
helixhelix

It takes a couple of weeks to build up in your body, so it can take a while to feel the effects - positive and negative. I remember for me the side effects got worse for 9 weeks, and then wore off. Your liver is able to repair itself very well.

However we're all different so if concerned discuss with your GP.

seneca profile image
seneca in reply tohelixhelix

Thanks so much Helixhelix - that's exactly what I needed to hear (that side effects can worsen initially). i will definitely go to GP if it gets any worse.

Laura_dilcock profile image
Laura_dilcock

My nausea continued to get worse and never eased. I switched to injections at 15mg, which helped for a while as it bypasses the stomach, but eventually at 25mg mtx I had to insist on stopping treatment.... the side effects were so bad for such little improvement for me. My blood results were fine throughout though, obviously just sensitive to it. X

seneca profile image
seneca in reply toLaura_dilcock

Thanks Laura, that's reassuring (bloods OK despite nausea) and troubling (neverending side effects) at the same time! I know I can switch to injections to bypass the nausea but I think I'm supposed to give it a good couple of months to see if the nausea passes of its own accord. Sounds like you had a really bad time with mtx. I hope you've found some meds that are kinder to you and more effective.

Laura_dilcock profile image
Laura_dilcock in reply toseneca

Hope the nausea wears off for you 🤞x

Laura_dilcock profile image
Laura_dilcock

Am trying azathioprine and prednisone at the mo. No side effects (apart from weight gain) but not great improvements either. Have just increased dosage though so fingers crossed 😊

seneca profile image
seneca in reply toLaura_dilcock

Wishing you the best. I work with someone who has been on that same combo (azathioprine + prednisone) for more than 10 years and she is doing really well - goes to gym every day. (Didn't know you could take prednisone for so long, though?) It's nice to see dmard success stories in real life.

Laura_dilcock profile image
Laura_dilcock in reply toseneca

That's great 😁 would love to get to a level where I can be more active again. Good luck with mtx, it works great for so many people so fingers crossed for you x

Not what you're looking for?

You may also like...

MTX nausea - should I be taking something?

Hi All. I've been very lucky to date not to experience any nausea after taking MTX but since rising...

Mtx and nausea???

Hi everyone, well this is my 3rd week taking mtx now and feeling a bit fed up. The first week I...
Rosie_rabbit profile image

Mtx and Nausea

I have been recently been diagnosed with PA and Mtx was mentioned but I am not on any meds yet. I...
mole147 profile image

Nausea and MTX hangover

I've been injecting MTX for a couple of years now but have noticed the last couple of weeks I have...

Splitting the dose of MTX?

HI All. As some of you will know I've been having some trouble with taking MTX lately re nausea...

Moderation team

See all
KateL-NRAS profile image
KateL-NRASAdministrator
Donagh-NRAS profile image
Donagh-NRASAdministrator
Nicola-NRAS profile image
Nicola-NRASAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.