Does anyone have any experience with infertility and RA? We have been trying to have a baby for about 8 years now with no luck. We have done 4 unsuccessful rounds of IVF. When i started the methotrexate I also started birth control due to the possible birth defect side effect methotrexate can have. I know the likelihood of becoming pregnant on my own is slim to none but it still makes me sad to know it’s even less possible now that I’m on birth control. My rheumatologist was really good about explaining other options if we were still looking into more fertility treatments but i really want to get my RA under control and he feels that methotrexate is the best option. My pain has substantially decreased since starting the mtx so i do think it’s working but the “what if’s” are so hard!