OH has now been on the combination of sub cut MTX, hydroxy and sulpha for 7 weeks (MTX for about 9 months, hydroxy for 4 months) and since starting the sulphasalazine seems to have become more poorly.
It may have reduced the evening fatigue a little and possibly reduced the chills he was getting, but if anything his joint stiffness and discomfort (hands, shoulders, hips and knees) is worse, his irritable bowel type symptoms are much worse, he's been itchy all over and generally just feeling ill most of the time.
I've just read a few old posts on triple therapy, and I see some have been unable to tolerate the sulpha and others have just taken a long time to get used to it.
He should have an appointment with his consultant in the next couple of weeks. When we last saw him he said if the DMARDS really aren't working, he would look at biologics, but it might not be easy to get them as not sure if OH will score properly (the consultant did say that he will make sure OH can get them if he really thinks it's worth a try, so that was reassuring). So, is there another option before that? Has anyone had sulfasalazine taken out and lefluonomide put in and has that helped?