Drugs or no drugs? I see my Rheumy next week. I am due for Rituxan in June. It has not changed anything so far. No improvement but no side effects , so far. I know she wants to treat Lymphoma, however, mine is Tclonal not Bclonal. I do not see how it will affect it. The other issue is MTX. I discontinued in Dec. I did not want to deal with side effects for holidays but then I could not talk myself back into injections. With my gene mutations I cannot process Folic Acid. My inflammation is low but not because of drugs. Disease activity has been very high but the doctors only seem concerned with CRP levels. My fear is MTX creates a dependency so that when you stop, for surgery or infections, flare begins. My body has not done that. Inflammation not affected by MTX only Prednisone. I did not react well to it, it made me crazy. But if CRP gets high I will consider short term dose. My question is regarding Biologics . If I have not responded well to eleven drugs, when is enough , enough? I keep waiting for the next major flare. How can you plan anything? It is so frustrating. I would prefer worse case scenario. I want to know what is coming.