Well I had my second infusion of Rituximab on Thursday. Took six attempts to get the cannula in so am a bit bruised. I know they said it can take up to 12 weeks to see a difference. What they haven't said is what sort of difference. At the moment I can't close my bra because I don't seem to have the strength in my arms. Hands and wrists and knees still ache. Just wondering if I can expect these aches to diminish considerably. Am so tired all the time as I can't sleep for the shoulder ache.