Methotrexate and nausea

[Fluffontoast]

Sorry if I've asked this before, but everyone I've heard of or asked, who is on the oral Methotrexate seems to get nausea. How long does it last e.g 1 or 2 days? Or constantly? Does it go away after some weeks or months? It's really putting me off.

[Runrig01]

I’ve been on it 7.5yr, and have never had any side effects, except for a slight thinning of my hair, which was very thick anyway. Forums like this don’t give you a true reflection, as those not having issues, are generally getting on with their life’s and not using forums. It has done wonders for my peripheral joints

[Fluffontoast in reply to Runrig01]

Thanks

[Amnesiac3637]

Have to say I couldn’t tolerate it, hated the nausea, brain fog, generally feeling hideous for four days out of seven but others have happy experiences and swear by it so it's very subjective as to how you react to it. Whatever, if you can’t put up with the side effects it’s not compulsory to stay on it!

If you’re not yet on it and worrying about nausea, it may not affect you at all and it’s still a good drug as a starter so worth giving it a go. If you’re already on it and suffering too much have a word with your rheumatologist and get MtX changed to something else.

Best of luck, hope you get sorted out with the right one!

[Fluffontoast in reply to Amnesiac3637]

Thanks I'll most probably give it a go

[Thingybob]

I had the nausea etc on the tablet form. I moved quickly to the injections. I still get after effects the day after but not as bad . I persevere with it as it seems to.work for my RA. You could ask your rheuny about changing to the injections ? Best wishes :).

[Fluffontoast in reply to Thingybob]

I'll probably try this first and give it a few weeks. I've mostly heard that the injections don't lead to so much nausea, so that's plan b!

[Neonkittie17 in reply to Fluffontoast]

Was about to say I switched to sub cut Mtx to try ensure a better result for my RA (it did!) the slight nausea I had before disappeared. Hope you can speak to your thumb re sub-cut Mtx.

[Fluffontoast in reply to Thingybob]

Btw are you a moomins fan?

[KittyJ]

I’ve been on it 25+ years and I don’t get nausea, I did at first and take folic acid so I no longer get it. It’s not a given you will get nausea but you won’t know if it’s the drug for you unless you try.

[Boxerlady]

I didn't have any nausea when I was on tablets, just tiredness about 24 hours after taking it. I moved onto injections to get a higher dose and have the same side effect; I find it perfectly manageable, though.I'd suggest that it's worth a try as it might be "the one" 😁 If it doesn't suit you, you can always move on but if you don't try it, you'll never know! I'm actually rather pleased that I didn't know anything about it beforehand - or any of the medications I'm on - because I had no expectations of problems and that can be very helpful. Try to be as positive and optimistic as you 😉

[Fluffontoast in reply to Boxerlady]

Ok, will do, thanks for that!

[Madmusiclover]

no nausea but didn’t feel great on 20mg. Currently on 10. No issues apart from tired the morning after.