I had my first cycle of Rituximab last November. I felt I needed another around April/May, but it was postponed so that I could have my knee replacement. I also had to stop Mrthotrexate two weeks before the op. Apart from the fact that I developed Cellulitis and that the first two weeks was much more painful than I expected, the new knee is a great success. In fact, right now, it's the only bit of me that doesn't hurt! I'm back onto MTX (22.5mg) but have had to resort to 10 mg Prednisiline to allow me to move! I had Rituximab infusion last Monday. The first day, I was a bit hyper, but since I have been completely wiped out. Thundering headache and feel really poorly. Joints painful, but also muscles and tendons. Can't do a thing but rest. Typing this post is my limit! I don't remember feeling this bad last November. Now, I'm rather dreading the next on the 22nd. I go on holiday on 2September. I tell myself that my response is this extreme because I've got so many naughty B cells ( my ESR AND CRP were sky high).
Has anyone else felt like this? Jora