I was diagnosed with RA about two and a half years ago. Since then I have only been on Minocycline and was doing fine. Until recently. Suddenly the joints in my hands have become inflamed and painful. Upon returning to my rheumatologist, he stated that Minocycline works well for some people for awhile but when it stops working, it stops working. He now has me on Methotrexate injections once a week. I have just taken my third injection. My question is, I have experienced what they call Methotrexate brain fog after the first two. Does this eventually go away? I am trying to time my injections out so they do not interfere with my job. I am also taking Folic Acid with it to help reduce side effects. Just wonder if this is something I will have to deal with or will it go away once my body gets used to it.