Ok, so here is another side effect of the methotrexate. When I inject on Friday night, I most always go down for a day or two. My wife complains that she has no life now. She says her weekends are shot, and she has to go out alone. She complains that I do not remember things, or I am not listening. It's all true. I inject on Friday night so that I get sick on the weekend not during the week. My wife loves to party, and go out with friends, and most of the time she has to do it without me. Does anyone else feel a little foggy I'm the head from the methotrexate? Does anyone else have a similar spousal issue.