My wife has had psoriatic arthritis for c.9 yrs. A very painful and debilitating condition. In 2008 her consultant (he's actually good guy) switched her medication from Methotrexate to Leflunomide. The ensuing events were catastrophic and almost fatal, and in a minute time scale. Her GP had patronisingly suggested she was overtired when she mentioned extreme tiredness, almost passing out. She was a head teacher, and ALWAYS in control, and his prognosis was so wrong. Luckily in the same week, she a had a clinic appt with her consultant. After initially asking how she was coping, without looking up from whatever he was writing, she replied 'none too well'. As a patient who never complains, he immediately changed tack, and suffice to say she was in intensive care within the hour, being pumped up with 3000mg steroids. Yes three thousand. Fast forward, ignoring the verbal inquests and apologies, the reality is that she suffered Instertial Numenitis, with irreversible lung damage. A joint report, authored by her consultant and another from another major regional hospital was flashed to the World Heath Organization with a warning that 'the use of Methotrexate and Leflunomide in close (timE0 proximity can cause fatality any time during therapy'. Last week, her GP and a trainee GP suggested she switched from Flamrase to Naproxen as the former causes heart disease . Low and behold, the Neproxen fact sheet warns it should never be used with Methotrexate as there potential fatal consequences. Flamrase is not available from the manufacturer until June 2014.
Does anyone have any personal experience of MTX with Neproxen?