Hi - I know some of you have had to take a break from mtx for various reasons. Any ideas how long you have to be off it before symptoms get worse. My GP phoned me this week when I put in a prescription request and said that according to my blood results from last week, one (don't know which) of my levels was slightly low and I should contact rheumatology - which I did. CNS spoke to consultant and rang me back to say I should leave off the mtx for 2 weeks. I wouldn't normally worry too much about this but my son is getting married 2 weeks tomorrow and I really do want to feel ok. It's bad enough that my nerve block injections in my spine (I have degenerative scoliosis) are starting to wear off so standing is getting quite painful and it's too soon for more injections. In addition to this the doctor is referring me to a dermatologist because of a suspicious spot on my leg. I know that won't affect wedding plans but it is just one more thing to worry about. Any comments about the mtx would be gratefully received.