Hi I have just started treatment and am taking methotrexate 15mg (second week) along with hydroxychloroquine and Buprenorphine 5mg patch. I am getting pain in my knees shoulders etc. I am coping during the day. However night time is a different story the pain in my knees is unbearable waking me throughout the night and walking in particular is getting very difficult yet the next day i can walk fairly well. I am so tired and finding it hard to cope because of lack of sleep. I only had the patches last week but they have made no difference. I am praying the tablets will work eventually but how do you cope in the meantime?