Since starting MTX about 8 weeks ago I've avoided taking any NSAIDs (Naproxen) at the same time ie I don't swallow MTX and Naproxen simultaneously. As a result I tend to go for about 24 hours between Naproxen doses once a week. I do this because I don't want to hit my liver/kidneys with Naproxen and MTX at the same time. Problem is that I feel dreadful without the Naproxen. Does anyone take these two together? If so have you had any adverse reactions? By the way I generally feel ok on MTX other than the usual tiredness and sometimes feeling slightly hungover the day after taking it.