change in eGFR

[Hylda2]

I have recently been put on a drug called Daplifagozin for heart failure. Had to have blood test of my kidneys after three weeks. My eGFR has gone from 47 to 58!

Can’t help wondering if I’ve got someone else’s results!!

Di

[Merny5]

Great news for you. Except those wonderful results

[nonna70]

Check with your doc; I hope they were yours ...

[PecanSandie]

from the American Heart Association: ...dapagliflozin reduced the risk of kidney and cardiovascular events in patients with chronic kidney disease and albuminuria with and without type 2 diabetes. Sounds like the drug is doing its thing! Good for you.

[Blackknight1989]

Since this surprise in a medical trial in 2020:

the risk of a composite of a sustained decline in the estimated GFR of at least 50%, end-stage kidney disease, or death from renal or cardiovascular causes was significantly lower with dapagliflozin than with placebo. (Funded by AstraZeneca; DAPA-CKD ClinicalTrials.gov number

I’ve begged my nephrologist, GP, and any other doc I’ve seen to prescribe it as it’s and other similar can stop eGFR decline completely in CKD patients for a currently unknown amount of time but it the most effective drug out their for eGFR decline and I cannot find a doc in BFE ARKANSAS to prescribe it…they all dismiss me say I don’t have heart issues…I’ve been to several (I’m almost embarrassed to reveal how many) and now have been put on the “naughty” list by a nephrologist group, “banned from changing doctors for 3 years unless a serious life-threatening or long-term type hospitalization risk is incurred for “doctor shopping!” YES I have talked to several lawyers and other specialists and yes these docs cannot legally treat a patient with such potential life-altering/ending lack of empathy but in reality, it’s a small rural area with the largest city 3.3 hours away, several towns of 30-75 thousand people and 1 nephrologist clinic per town, they all are buddies and so one group called the other 3, plus they all reached out to the GPs now, to effectively agree to not treat me if I seek a second opinion. They believe me trying to “Find an uninformed medical professional for unapproved RX of specific medications for off-label use to treat CKD though not approved and not shown to benefit CKD” is both dangerous and potentially the criminal offense of “doctor shopping.” IMHO, they will slow their rush to try to make mine a cautionary tale, one one of them reads the December ‘24 Nephrologist journal with the landmark med study verifying both the benefit and approving of this class of drugs to stop the decline of eGFR number in its tracks… but currently what I’m facing is typical of small-town hero worship creating almost pathologically demented and Super-Over Ego inflated Godlike worshipping of the doctors who sacrificed their earning and living conditions to live in a rural, lower-populated area simply to help the underserved citizens access top-specialists med care… meanwhile my eGFR is 16 and I can’t get a safe drug proven to stop it from going to 14…AMAZINF!

[Hylda2]

OMG! I know we blame our NHS service for a lot of woes but I have had nothing but help.

I am 81 and have a pacemaker. I was reduced to 30mh Edoxaban because of my kidneys. Luckily I decided to pay privately to see my NHS Cardiologist and she suggested Daplifagozin. I still cannot believe the results.

I can understand your desperation.

Di