Extremely SILLY question but I had to ask it . Most of the Protein found in Urine is Albumin because its small in size & it can easily pass through or is the first to pass through a damaged tubule . But why on earth there's so much difference in the value defined by doctors on how much albumin in urine is Fine per day vs Total Protein per day .
Normal Values:
Albumin in Urine should be < 30mg/day
Total Protein in Urine < 150mg/day
If most of the Total Protein is Albumin then shouldn't the value be higher ? Anyone ?
I couldn't resist asking this
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Imviiku
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Youve stated that Albumin in Urine should be < 30mg/day but where is that from? 24h figures at least for our records in the UK are only provided for total protein - with a similar figure to that youve quoted for protein.
Did you mean 30mg/g or 30mg/mmol for normal and severely increased albuminuria respectively? For example, in graph shown in kidney.org/content/kidney-f...
Our surgery records do not supply a normal range for reported urine microalbumin figs.
There are literally thousands of proteins in the human body, albumin is only one of many. Albumin and other proteins are supposed to stay and work within the body so it can function properly and stay healthy - helping the immune system or building bones and muscles, and so on. Different proteins do different things. If the "screening" filters in the kidneys aren't working properly, any number of proteins, including albumin, can flush through and and wind up in the urine. (I simply picture a screen with holes in it and proteins falling through it into the urine.) So it's wonderful when labs show no, or very little, albumin or other proteins in the urine at all. The test for albumin is very sensitive, an early detector of one protein, and separate from the others. The proteinuria test is an older test and looks for protein in general, including albumin. So, expect the proteinuria test to present higher numbers.
albumine when you spill as well that protein the main one witch is called albuminuria or proteinuria when albumin is not there witch is worser albuminaria you start to retain liquids and water witch is the one in charge of taking them out
Albumina and UCAR that other blood test necessary for a true diagnosis of CKD according to NIH, NKF etc…UCAR is a measure of total kidney damages especially in T2D CKD patients…more serum albumin and more excreted in urine is perhaps the best predictor of kidney health and prognosis for CKD progression…we here get so hung up on eGFR and “fixing” that lab to “cure”(no cure as we don’t regenerate nephrons like we can liver or skin cells) and while an increase in eGFR is a sign of hope we all seek it doesn’t mean despite what some believe that our kidneys have more nephrons than they did when we were diagnosed only that they are “unloaded” the risk of sudden AKI has been reduced but not back to levels that those with healthy kidneys enjoy…that is especially relevant today as both COVID and the COVID vaccine drove up all cause mortality in those of us with near ERSD stages of CKD…here is a link to the science behind this fact and I must add a very astute question…hero that kind of thinking and make sure to act on it as your CKD outcome will be improved!
In a large cohort of CKD patients, a higher UACR at time of diagnosis was associated with increased risk for renal events—loss of half of eGFR, dialysis, or death. (Chronic Renal Insufficiency Cohort study
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