Remyelinating medication in trials!

[Cwright170994]

Hi everyone who has damaged nerves with demyelinated nerves (mainly MS patients, me included)! So, I've read this morning that there's a drug in clinical human trials going on, and I'm hoping it'll pass and be allowed on the NHS 😍🤞 please see article linked below 😁

multiplesclerosisnewstoday....

[Frances_B]

Same comment that I made to the other post about this trial:

Phase 1 means that the drug has actually moved to being tested in living organisms i.e it's no longer being tested "in vitro" ('in glass") but is now being tested "in vivo" ("in living organisms").

Often the time frame between a Phase 1 trail and the drug being released for general prescription to patients is around 4 or more years at the very least - and that is only if it proves to be effective and does not have too many side effects which outweigh its possible benefits. At least if a drug gets to Phase 2 or 3 you know it's not likely to have death as one of its side effects......

So, Yes, optimism is allowed but real life times frames generally mean tempering that optimism with a strong dose of "I'll sit up and take notice once it's actually available to patients" is the only advisable approach , especially as the number of drugs which go through early clinical trials but never make it to market is very significant.

[Cwright170994 in reply to Frances_B]

It's currently in phase 2/3, as they've got volunteers to test on.

[Frances_B in reply to Cwright170994]

That would be very strange - the article you linked is the same one that bxrmom quoted from and it says that the clearance is for a Phase 1 trial. Clinical trials cannot not start a Phase 2 until the Phase 1 stage has met its endpoints, ditto for going from Phase 2 to Phase 3 - regardless of whether there might be volunteers will to try something (after all, a trial "volunteer" is just a person who has held their hand up to be part of the trial).

The drug manufacturer running the trials shows on its website that they are ready for Phase 1 only.

phenotherapeutics.com/

Screen clip from website showing clinical trial phase for drug PTD802

[Cwright170994 in reply to Frances_B]

Ah, thanks for catching that 🫣 didn't do a good read of it.

[starlight5]

Thanks for the link 😊