This study was published 10 March 2025.
High-dose vitamin D reduced disease activity in clinically isolated syndrome (CIS) and in early relapsing-remitting multiple sclerosis (MS), the D-Lay MS clinical trial showed.
Key Takeaways
High-dose vitamin D reduced disease activity in early MS and CIS compared with placebo.
Patients taking vitamin D had a longer time to disease activity: 432 days versus 224 days.
No severe adverse events were related to high-dose vitamin D.
Thank you for your post!😀 Leslie
Ah, kinda makes sense 😅 I wasn't outside enough times due to work, school, and not wanting to go out because I'm reading a book or something 😅
Very high dose of Vitamin D was used. Thanks for posting!
've had high dose vitamin d completely shut down Ms flares and attacks. My neurologist always worries that my vitamin d is too high. I keep it around 100. Because, under 40 is an automatic MS attack flare. Vitamin d is more powerful than any disease modifying crap drug I've taken in the past.
I suspected as much. I worked for years in an office with no windows. In the winter, that meant going to work in the dark and by the time I was done with work, it was dark again. Lunch time was the only light I got. Not nearly enough light.
I had a high dose vitamin d injection once a week for almost a year, almost 20 years ago. I did have an adverse reaction. Severe constipation. I did not go to the bathroom by myself for over a year. I should have bought stock in fleet. Tore me up. We just never connected the dots until after I stopped going to this doc. He was an alternative doc that we had decided to give a try. He was spot on about almost every thing except this for me. Might have just been my system and the way that it works. I still have issues. I am now on 5000 ui a day. My neuro tests my vitamin d levels once a year. Not covered by my insurance. If my levels are low then I am on 10,000 a day for a week. Just be aware.
After I was first diagnosed, my family dr tested my Vitamin D levels and they were really low so I had to take an rx strength for a month and then retest. My numbers were then in range and I was instructed to take 1,000 iu twice a day. I have been on this same dose since 2007 and I have my levels checked every year (or every other year) and they are within range so I have not had to change anything as far as the dose or frequency.
I have been doing high dose vitamin D (Magnesium and K2) since, 2020. And, I am actually better than when I was disease modifying drugs. My medical team keeps say that my vitamin D level is toxic. But, they remark that I am doing better. Too bad we can't get doctors to work with us with vitamin D; but, the drug companies work with medical schools, and give incitives to push medications. Doctors go to medical school not health school
Thank you for posting this. I've been taking 5,000 IU/day of vitamin D3 for years now and like to think it's helping me. I started this years ago when my doctor recommended it but it was many years after I'd been diagnosed with MS. It looks as if there is evidence that newly diagnosed people are definitely getting some benefit from supplementary vitamin D3. Maybe those who have had MS longer will be helped too. And it's pretty hard to overdose on it.
Different Types of MS
Ocrevus starter
