Tysabri to Ocrevus?

[CatMom3]

I've had MS for nearly 30 years and I have been receiving Tysabri infusions since May 2012, but my MS has progressed and I've spoken to my doctor about switching to Ocrevus. I'm just wondering if anyone else has changed treatment and how did it go? Has anyone had positive results?

[Xvettech]

I’m sorry catnom! Idk. Mostly because I have the cancer gene and couldn’t have those medicines, I hope it all goes well for you!

[Xvettech in reply to Xvettech]

P.S. I love your handle

[CatMom3 in reply to Xvettech]

Thanks!

[Xvettech in reply to CatMom3]

Your welcome

[Amore55]

I am so sorry that your MS has progressed. When I was on a DMT I loved the tysasbri. I was never on the other one so I can’t offer any advice, but I wish you the best in your future.

[CatMom3 in reply to Amore55]

Thank you!

[jkdavid99]

I have tried tysabri and had bad side effects so I stopped after first dose. I also tried aubagio with more terrible side effects so I stopped that one. I was also on rebif for 10 years . That stopped working. Now I am on ocrevus. This is a good therapy for me. I did have some chest pains in the beginning like 3rd infusion so now my neurologist runs saline at same time at ocrevus ocrevus. And slows down the drip, Much better. No new lesions in about 4 years. I like this stuff and I am the biggest chicken at taking drugs. If you choose ocrevus good luck to you.

[bulldogman]

I switched to Ocrevus from Tysabri 2 years ago. I did a washout of 2 months then started Ocrevus without any problems.

[Cwright170994]

I was on copaxone for 5ish years, before they tried me on tysabri. That was a no-go because, at my one and only infusion of it, my bloods came back as JCV antibody positive, with a high titre. So, back on copaxone I went, for a few months, until the neuro had enough evidence to start me on ocrevus. That is a wonderful DMT! They should have started me on that one, otherwise I wouldn't have moved from simple partial seizures to generalised ones 😒 the ocrevus is keeping the number of lesions I have stable, so that's definitely a winner for me 😁

[Elizt3]

I have had MS for 28 years and been on 6 DMTs. Back in 2019 I switched from Aubagio to Ocrevus because I had new activity on an MRI. Since going on Ocrevus, I have had no new lesions on MRIs. I recommend Ocrevus - no side effects (once we added IV Pepcid before the infusion to take care of reflux symptoms). Switch from one drug to the other went smoothly. Best wishes!

[MNM3708]

I began Ocrevus in June 2022 after my MS diagnosis and have been stable with no new lesions, per MRIs, since that time. It is hard on my GI system, so I drink Enterade for three days leading up to infusion and three days after,

I have been diagnosed with breast cancer and, because of this, my Ocrevus infusion that was due a month ago was held. Tomorrow I will have bilateral mastectomy and reconstructive surgery, My oncology surgeon, my MS neurologist, and I will discuss post-op regarding the possibility of resuming Ocrevus. I hope to be able to resume it! Good luck to you!

[Greentime in reply to MNM3708]

Oh my, best of luck with all of this. 🤗

[CatsandCars in reply to MNM3708]

MNM3708, I'm so sorry to hear that you have breast cancer and need a bilateral mastectomy. That must be so frightening. Sending hugs and praying your surgery goes well. ❤️🙏❤️🙏

[807lane in reply to MNM3708]

May everything go smoothly and may you have a swift and easy recovery. Wishing you strength and good health."

[mhepler531 in reply to MNM3708]

Prayers for your surgery and recovery. 💕

[sashaming1]

I switched from Tysabri due to a high “JC” blood count to Lemtrada. Both stopped new lesions. I did have frequent UTI’s after though.

[AriSmyelin]

I was on Tysabri for years and loved it (but my veins hated it) I had to change due to becoming positive with JCV. I went to Ocrevus and have now been on it for 3 years. I am doing really well. This is my 5th treatment in 13 years so that is saying something. I was tired with it at first because it it's literally your battling cells dying, the very cell that's supposed to protect you. Now I am all good. Sometimes I am a bit tired afterwards others not. It takes about 6 hours. I have now been approved for the faster input 2-3 hours as I was the only one they have seen who handled it just fine especially considering I refuse to take the Solumedrol they give you. (It doesn't work for me). I do like it, mostly because I only have to do it 2 times a year. Sorry if that was way more info than you were looking for. Best of luck on your decision and future treatments.

[Cutefreckles72]

HI CatMom3, I have PPMS. I was diagnosed in 2019 and the first DMT for me was Ocrevus and so for I haven't had any problems. Next month will be my 12th infusion.

[Haku949]

CatMom3 my son recently was diagnosed just a bit over a few months ago...He is on Ocrevus- the nurses are very tactical during his appoinment. So far no issues - he is in his early 20s...But always go with caution each person reacts differently. Sending you good vibes

[Anijah]

I switched to ocrevus n it was great 👍 best drug to slow symptoms. Unfortunately insurance stopped covering after 2 years n now on Kesimpta which works slightly less but still ok. Happy trails on your journey. I had no side effects with the switch

[Tazmanian]

I was on Tysabri years ago several DMT's later I was on Ocrevus I liked both but now I'm on Keysimpta Ocrevus worked well for 6 years but nothing lasts forever

[mhepler531]

I took Tecfidera for about 12 years. No side effects except occasional flushing. Worked great and just 2 pills a day. In 2022 I was hospitalized for about 4 months (not MS related). After that I had no DMT until the beginning of this year. Switched to Kesimpta and it seems to also be going well. No side effects and no noticeable progression to date.

[bpriddle]

I have been talking tysabri for around 7 years. I had a follow up with my doctor this week and have had no progression to date. My legs are getting weaker however I am also 72 years old. I am using a walking stick or cane for stability. I have had my left knee replaced and next will be my right hip

[Jaycole24]

I was on tysabri I ended up switching to ocrevus though but only because I was positive for the brain virus you could get and it’s been working well for me being on ocrevus. So I’d say it’s a good choice if that’s what you decide.

[DIsneyQueen]

I was on Tysabri and then switched to Ocrevus. Did fine on both. Had no issues, but don’t know if there was a big benefit for either. But didn’t get worse.