Bladder Botox

[Disneycde]

Hi. Does anybody have thoughts on this? Does it help incontinence?? Does it worsen the inability to empty the bladder. Have started to consider this and was interested in personal experiences. Thx

[kycmary]

I have heard of Botox for lots of things I still say "Why take a poison to fix anything? This is the first for bladder problems, I personally wouldn't do it & I have had bladder urgency & leaking since I was in my 20's. I wear pads 24/7 & at times had to use a diaper I am now 69 in 2 months. Think about this every commercial I have seen advertising Botox they alway say "it may spread to other parts of your body" & give a list of things that could happen! Please be careful as one of the things is death & there's no fixing that! Mary ur sister in MS.

[Sandydemop in reply to kycmary]

Hey Mary, i'm thinking about botox. my friend had it. said it helped for a couple of years.

[kycmary in reply to Sandydemop]

Hi Sandydemop everyone has the right to do what they want don't let me interfere with it, that is my opinion of Botox. I have heard things both good & bad about it. I do not have any personal experience with it. A question was asked & I responded to it that simple, good luck if you do decide to do it, I would be interested to know how it works. God bless you. Mary.

[Disneycde in reply to kycmary]

Thx

[JMWCO]

I’ve been doing PNTS treatments for over 1.5 years. When we were discussing options heading into PTNS it was brought up as an option.

I’ve been content wit the PTNS and I did 6+ months of pelvic floor work with a physical therapist that specializes in pelvic floor.

No more post baby leakage (you know sneezing, jumping, running), the PTNS keeps the urgency and regular leakage under control.

When I asked for treatment options everything was - we can try this, then this and so forth. I liked that they had levels of treatment for different severity. As for it being actual Botox- I’ve gone to find mist drs call it Botox but it’s a filled like substance to help the muscles do what they are supposed to. Usually if you get the fun and exciting bladder test they can tell how much water you can hold, if the muscles engage like they are supposed to and more. Not pleasant but informative in treatment options.

Good luck 🍀

[starlight5 in reply to JMWCO]

Can you explain a bit more about PNTS please. I just got a script for pelvic floor therapy. You can PM me if you want.

I had the urodynamic testing done about 7 years ago and did a round of pelvic floor therapy. Compared to now, my bladder issues back then were practically nonexistent.

[JMWCO in reply to starlight5]

It’s pretty much a tens unit for your nerve that goes by your bladder to help regain control- regarding urgency/leakage and the like:

en.m.wikipedia.org/wiki/Per...

I was nervous at first when I went and the realized it wasn’t a big and the benefits last a month.

Hope that helps!

[starlight5 in reply to JMWCO]

Thanks!

[kycmary in reply to JMWCO]

I tried those pelvic floor exercises my hubby liked it as I was always ready for sex not any more.

[MsBoo]

I have it done whenever I go thru 6 max poise pads (pee pads as I call them). It usually lasts for about 6 months for me.. I have had the pelvic floor therapy done, Pills (some of which have helped), but alas I have no feeling of urgency anymore.. the nerves are just shot.

So, I would say if your are in my boat.. do it.. but try everything before.

But it is your choice.. in short, it has helped me.

Haha and that is my 2 cents.

Have a good day.

[mrsmike9]

I have a med that helps me not lose it. The only drawback is it makes my mouth a tad dry but at least I'm drinking more water!

[sashaming1]

FYI, I haven't tried it, but here is one of the things I've read:

"Low-dose Botox Treatment Improves Urinary Symptoms in MS Patients, Study Finds

AUGUST 9, 2018 Stacy Grieve, PhDBY STACY GRIEVE, PHD IN ALEXA, NEWS.

Results from a Phase 3 clinical trial show that urinary symptoms can be reduced significantly after treatment with low-dose Botox (100 units) in patients with multiple sclerosis (MS).

That finding was reported in the study “Low-dose onabotulinumtoxinA improves urinary symptoms in noncatheterizing patients with MS,” published in the journal Neurology.

Most patients with MS develop neurogenic detrusor overactivity (NDO). The detrusor muscles are part of the bladder and are involved in bladder contractions. Because of nerve damage caused by MS, the communication between the spinal cord and the bladder is disrupted and the detrusor muscles become overactive. This results in sporadic and frequent urine leakage. Not surprisingly, NDO can severely affect MS patients’ quality of life.

Treatments for NDO are usually invasive, and may include surgery and the use of implantable devices.

Botox (onabotulinumtoxinA), a minimally invasive option, is approved for the treatment of NDO associated with MS. Studies have shown that injections of Botox (200 units) can reduce urinary incontinence and improve the patient’s quality of life. However, high doses of Botox are associated with a potential risk of complications, including urinary retention requiring clean intermittent catheterization (the insertion of a catheter into the bladder to help the person urinate).

A previous Phase 3 trial (NCT00910845) testing Botox in patients with idiopathic overactive bladder with urinary incontinence (non-MS patients) showed that Botox at 100 units (half the dose) could reduce urinary incontinence.

In 2015, researchers completed a Phase 3 trial (NCT01600716) to assess the safety and effectiveness of Botox (marketed by Allergan) at a dose of 100 units in noncatheterizing patients with MS and urinary incontinence due to NDO, to determine if the lower dose could reduce urinary symptoms in these patients.

The trial included 144 noncatheterized patients with clinically stable MS, and a history of NDO for more than three months. These patients were recruited from 58 sites across North America and Europe between July 2012 and March 2015.

In total, 66 patients received 1 mL injections of Botox (100 units) distributed evenly into the detrusor muscle, while 78 patients received injections of a placebo. Patients were followed for 52 weeks (one year), with check-ups at 2, 6, 12, 24, and 52 weeks.

Significant decreases in urinary incontinence episodes in patients treated with Botox were seen

as early as two weeks after the injection. This trend continued through week 12. At week six, more patients treated with Botox reported a more than 50% reduction or total reduction in urinary incontinence episodes per day, compared to patients treated with placebo.

Botox treatment also increased the maximum cystometric capacity — referring to the volume at which the patient feels he/she can no longer delay urination — compared to placebo, and significantly decreased the pressure in detrusor muscles.

Results showed that while symptoms of urinary incontinence decreased, bladder function improved.

Regarding incontinence-related quality of life, greater improvements were seen in patients treated with Botox.

Importantly, treatment with Botox was long-lasting. Duration of Botox’s effect (i.e., median time until request for another treatment) was 51.7 weeks, compared to only 12.6 weeks in patients treated with placebo. Only 45.5% of patients treated with Botox requested a second dose, while 85.9% of patients treated with placebo requested a second treatment.

Botox was generally well-tolerated, and adverse effects for this treatment were low. The most common adverse event reported was urinary tract infection (25.8%).

Overall, the team concluded “in noncatheterizing patients with MS and NDO, treatment with onabotulinumtoxinA 100 [units] results in significant and clinically relevant improvements in UI [urinary incontinence] and other urinary symptoms, urodynamics, and QOL [quality of life]…than previously reported with onabotulinumtoxinA 200 U,” they wrote.

The team also emphasized that “more than half the patients (53%) treated with onabotulinumtoxinA became incontinence free (i.e., “dry”) at week 6 after treatment.”

Of note, the study was funded by Allergan, and the results are specific to the Botox formulation used. Other botulinum toxin products may not have the same results."

[kycmary in reply to sashaming1]

That is very informing information thank you. Mary