Ocrevus News from ECTRIMS

[Raingrrl]

businesswire.com/news/home/...

There is a bit of good news for RRMS people in that there is new data showing Ocrevus significantly prevented progression over Rebif when measured by a new measurement (PIRA).

Personally, I take this news with a grain of salt because it would be more useful to me to see data measuring Ocrevus against a tier 2 or tier 3 DMT not a tier 1 interferon. I'm still concerned about switching from Tysabri to Ocrevus when this has not been studied at all.

[erash]

Raingrrl

Pharmaceutical companies typically compare their drug to either placebo or a tier 1 type drug. They want good outcomes for the study, of course. It would be interesting to see them compare Ocrevus to their own other drug Rituxan.

Nonetheless, it's good news and here in the chat room people seem to be having good responses.

What is PIRA?

[Raingrrl in reply to erash]

erash ...I agree it would be interesting to see Ocrevus compared to Rituxan.

PIRA is a new measurement that was also presented at ECTRIMS. Its Progression Independent of Relapse Activity. This is from the article "PIRA is a newly emerging MS endpoint intended to measure an increase in disability, which is related to underlying disease activity in RMS." There is more details in the article. I think it is going to be a more useful measurement than just MRI's.

[erash in reply to Raingrrl]

Raingrrl

That's me PIRA

I'm gonna research that

Thanks!

[Hidden in reply to erash]

Hello @Raingrrl & @erash , My Dr wanted me to switch from Tysabri to Ocrevus but there's a high incidents of Cancer in my family so I opted out. I decided to go off meds all together & try the Wahls Protocol . My symptoms have diminished & I feel 100% better. I've lost 83 lbs in less than 7 months. Good luck.

[erash in reply to Hidden]

Hidden

that's wonderful!

[Raingrrl in reply to Hidden]

Hi Hidden ! Congrats on the weight loss! I don't think I'm disciplined enough for the Wahls Protocol so I admire anyone who gives it a try.

I asked my neuro about the incidence of cancer with Ocrevus. He asked if I have a family history and when I said I don't, he said that I should be ok on Ocrevus just make sure I keep doing regular exams and mammograms. This didn't make me feel all that reassured to be honest.

[Juleigh21]

Raingrrl I am on Tysabri and doing much better compared to when I was on Copaxone or Tecfidera. I'm watching the ocrevus studies closely but have no intention of switching unless my JCV status changes.

I would also LOVE to see a study comparing rituxan and ocrevus but greatly doubt it will ever be done since the same company manufactures both and one is inexpensive and the other is very expensive!!

[Raingrrl in reply to Juleigh21]

Juleigh21 I've done really well on Tysabri too and also was switched to it when Copaxone stopped working for me after about 12 years. Unfortunately I'm JVC positive and have been from the start of Tysabri. My index has continued to increase which is why I'm switching to Ocrevus. The other durg my neuro wanted to consider is Gilyena but I can't take it due to heart rate issues that I'm treated for.

[Juleigh21 in reply to Raingrrl]

Good Luck Raingrrl on ocrevus! I hope it works very well for you!

I'm fortunate to be jcv negative.

[Raingrrl in reply to Juleigh21]

Thanks Juleigh21 ! I hope you stay JCV negative. Too many of the drugs have a risk associated when you are positive.

[Sggmcswain]

Went from Copaxone to Tysabri to Ocrevus. Loved Tysabri, while it worked.

[Raingrrl in reply to Sggmcswain]

I'm following the same path Sggmcswain . Copaxone stopped working so I was switched to Tysabri. It has worked well for me but my PML risk is too high so on to Ocrevus.

[Sggmcswain in reply to Raingrrl]

Good luck - please let me know how it goes. Praying