and an explanation why it has taken so long, an FDA hold a few years ago:
Oct 2021 "The FDA has removed the full clinical hold that had previously been placed on trials evaluating rusfertide (PTG-300)"
They were monitoring mice on it and "found benign and malignant subcutaneous skin tumors" Seems ok in humans since trial resumed, but no doubt they are watching carefully. Sometimes they use very high doses in these sort of non-clinical studies, but it's not specified.
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One application for Rusf may be HCT resistance on IFN, a problem we're seeing regularly on the forum.
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EPguy
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Good news! My Mayo MPN recommended this for iron deficient, phlebotomy dependent people like myself. Will also help keep HCT stable. He said the only draw back is the injection site gets extremely irritated and must have injection every week. He said there is a better drug in the works (Disc) that he is hoping to put me in the clinical trial in the fall. Basically does the same thing but much less side effects. He highly recommends this one heading for clinical trials.
I think there is a new Disc drug trial coming out in the fall which may be different than the above links you sent?? Not entirely sure how different they are. Iron retention is involved with both. Will find out when I see the doc next time.
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