CRISR CAS 9 gene editing tool and polycythemia Vera JAK 2 positive

[Iwillwin123]

Hello ,

I wanted to know if anyone had any recent updates about using the CRISPR CAS 9 gene editing tool to address jak 2 positive Polycythemia Vera. Are there any clinical trials going on with this new tech ?

Regards

Iwillwin123

[Manouche]

Nope, but there are some other good news about PV research:

« In summary, our results suggest that DUSP1 addiction in the early stages of PV offers not only insights into the unique pathobiology, but also a potential therapeutic target, as inhibition of DUSP1 leading to JNK/p38MAPK hyperactivation may provide a strategy for elimination of the cycling JAK2V617F+ progenitors »

nature.com/articles/s41388-...

[Iwillwin123 in reply to Manouche]

Thankyou for sending the link. Plan to read it over the next 3-4 days in careful detail. This work is being done in the Czech Republic as I can see. Is the only group working on this or are there others that you would know of ?

Regards.

[Manouche in reply to Iwillwin123]

What about this one ?:

« Loss of DUSP1 Is Synthetic Lethal to JAK2V617F »

... « Thus, providing a rationale for targeting the Dusp1 in Jak2 mutated MPNs to eliminate the mutant clones and cure the disease. »

ashpublications.org/blood/a...

[Iwillwin123 in reply to Manouche]

Yes this concept makes so much logical sense indeed . I found also that there is at least one patent already pending regarding a version of this concept . The lesser the time required for reliable molecules to hit the market - the better it is !

[mhos61 in reply to Manouche]

Thanks for that link. It does sound very encouraging.

Bless these scientists who work on our behalf for a cure. A complex jigsaw they work.