Hi All, I just heard about another antibody treatment for CALR MF and ET that is in clinical trials with Janssen (J&J). Incyte of course also has one in the clinic (also Phase 1). This is very good news. It's still early days but nice to see another potential treatment option being tested.
link below:
CanadaG, interesting indeed, but not the kind of literature that most of us read. Are you a scientist yourself? Also, I assume we will need another 6 or 7 years to finalise development of this product, and hope that it ever gets that far.
This is awesome news. My hematologist at md Anderson mentioned this to me yesterday at my quarterly blood check (I have CALR). Lots to be excited about. ✌🏽
Hi, am guessing these trials are not in the UK at present?
Thank you for posting. I was aware of the Incyte trial with the INCA033989 antibody currently in early Phase I but it's good to know that another antibody candidate is also under development. Encouraging news for all of us CARLmut patients.
This is indeed good news. They have reported preclinical research on an antibody to all of the CALR mutants. The nice twist for this particular antibody is that it was designed so that it not only binds to the mutant CALR, but it also has another moiety that binds T cells. So, the mechanism is to attract T cells, which will then kill those cells containing the CALR mutant. Of course, this lowers the burden of the mutant with the potential to reduce (reverse even?) progression of the disease and diminish symptoms. The work reported only covers mouse models and blood samples from patients.
Indeed, it will take a long time to see if this will prove clinically useful to patients, but it is good to have an additional approach to our disease.
Can anyone tell. Me what calr is
December 22, 2022: Monoclonal Antibody Shows Promise for Treating CALR-mutant MPNs in Preclinical Study
Pegasys is applying for formal approval in MPN treatment
INCA033989 phase 1 clinical trial is recruiting patients 
