CALR Antibody

[CanadaG]

Incyte has started Phase 1 trials for their CALR antinbody. They have high hopes for it. Below is a quote from their Chief Science Officer on their recent quarterly call with analysts.

"And then also just to remind you completely different efforts, the CALR antibody is in the clinic now. Potentially disease modifying dash even curative in the 30% of CALR patients that are in the MF population and in the ET population. And that could be a completely different way of thinking if you can eliminate the clone and change the disease trajectory completely. And you wouldn't even be thinking then in terms of spleen and symptom response, you'd be eliminating the clone. So that's where we are with the program at the moment. Thanks."

[hunter5582]

This is a potentially a very big step forward. Hopefully the CALR antibody will live up to its promise.

[EPguy]

Great to see it starting. We've discussed in prior posts that CALR is uniquely suited for these new therapies since it is readily recognizable in the body. In contrast Jak2 will likely require an "uncloaking" step before these therapies will work.

This is probably the trial they refer:

classic.clinicaltrials.gov/...

They will include combo with Rux for one arm.

They are accepting pts from many countries, but the US is not one of them.

[Wyebird]

Gosh thank you, I had no idea this was going on.

[AndyT]

Early days but great to see this progressing, with hope that we may finally see a move towards cure rather than just treatment of the risks and symptoms of CALR ET

[dbus1417]

👌🏽🤞🏽💪🏽

[Tyce500]

Do you know if they are having any trials in the UK please?

[CanadaG in reply to Tyce500]

Yes it looks like there are some UK locations.

Please see the below link:

classic.clinicaltrials.gov/...

[Tyce500 in reply to CanadaG]

Thank you!

[tigerlove3]

WOW this is awesome! So glad to see more research starting