combo Jakafi and Pegasys

[william-Indo]

i am just stated the combo treatment of Jakafi 20mg twice perday + Pegasys 135mcg weekly for PV and it success to reduce my PLT from 1.2mi to 300k; HCT from 47 to 41,3; WBC from 27 to 16 and HGB from 18 to 14.

does anyone with same treatment can share their experience with this combo...?

thanks

[PhysAssist]

Hi William,

I guess there isn't anyone else [just yet], though I bet there will be soon-ish, because the one study I saw about the combination showed that it improved [the otherwise difficult] treatment outcome of combined JAK2 and [I think] TET2 mutation-based MPN's.

Sounds like it's a good match for you- are you aware of any side-effects? Have you been trialed on any other medications besides aspirin and blood-letting?

God bless and stay safe/well!

PA

[william-Indo in reply to PhysAssist]

Thank you and God Bless You too

[william-Indo in reply to PhysAssist]

I had treated with HU and Jakafi, and phlobotomy.

Still want to know the side effect in long term from other who has with this combo

[EPguy]

I saw your prior post you were on 15mg/day Jakafi , and now 40mg total per day. Did you try that much higher dose before adding the PEG? Or was it only 40mg + the PEG that reduced your blood counts?

[william-Indo in reply to EPguy]

Jakafi alone not working well to me, even my Hem up the dose to 20mg twice perday, HCT, HGB, PLT & WBC keep rising.

Change my hem sinced she said no more treatment to offer

New MPN specialist use this combo and I am happy with the result so far.

[EPguy in reply to william-Indo]

That's great results. So glad you found the right Dr. It does seem not many patients have this combo opportunity outside of the trial in that report.