Antiviral side effects?

[Loubprv]

Afternoon all,

Has anyone who takes Hydroxicarbamide yet taken Lagevrio ( also known as Molnupiravir)? I don’t have Covid. This is a question posed to me by someone else who is worried about side effects.

Thanks, Louise

[EPguy]

If you may consider an anti viral, Molnupiravir is not that great, only 30% efficacy.

nature.com/articles/d41586-...

In rare cases it can cause abnormalities in <<hematology (hemoglobin, platelets, and leukocytes)>> Not so great for MPNs.

reference.medscape.com/drug...

Some studies found Molnu no better than placebo.

If you have access to Paxlovid, that had much better effect, ~90% and its adverse effects do not seem to include Hematological. Liver and kidney impaired patients can be a concern same as with many of the meds we already take.

fda.gov/media/155052/download

Good idea to discuss with your Dr.

[Loubprv Volunteer in reply to EPguy]

Thanks so much. The Molnupiravar is the only antiviral that the gp stocks ! They’re really a bit hopeless with rare stuff. There is a question of compatability of Paxlovid with levothyroxine and loratidine - both of which I take, and Robapreve contains l- histidine which is a precursor to histidine and I have histamine intolerance!Still, will pass on your info which is jolly useful to all !

[EPguy in reply to Loubprv]

Thanks for the details, always learn new stuff on the Voice.

I do see this long list of interactions

ema.europa.eu/en/documents/...

it seems to enhance Loratadine. Anyway it clearly needs expert's attention to use.

[Loubprv Volunteer]

I m going to take my chances. Don’t intend to take any antivirals after a run in and severe consequences with Nitrofurantoin.

Had my 4th booster yesterday with no ill effects ( beginning to wonder if it’s had any effects at all!) However, I don’t intend to lock my myself away and have just booked flights to Malta in April. Fingers crossed no more variants…….