Post by MPN-MATE Admin » Sat Jan 30, 2021 12:05 pm
Morning all...
Well while the CV–19 virus continues to mutate globally, we are now all also becoming aware of the fact that no one will be safe unless we are ALL SAFE!
Hopefully, that knowledge alone might help us all better understand the need for empathy for everyone...
One of the latest reports to have recently surfaced was that about Astra Zeneca (AZ) not being appropriate for the 65+ Aged group. An earlier report out of Norway suggested that as many as 33 may have perished because of vaccination side-effects of the Pfizer type...
Hence, what has become known is that very little real testing has been thus far performed on many groups who might be more vulnerable than others...
This latest Report below goes into further detail which helps to shine a light on this continuing CV–19 pandemic globally.
Stay safe & well...
Steve
JANUARY 29, 2021
Germany expects EU to OK AstraZeneca vaccine with age caveat
And France have come out and joined them. No surprise their steve! But your certainly right about the lack of testing on different groups who might be more vunerable than others. I hadn't seen the Norway report. Thanks for the link. Tina.🤗
Just remember that not ALL reports are always factual. For example, it appears that the first report out of Norway, was in fact incorrect and exaggerated, whereas the Norwegian government and a great many other media outlets reported the event correctly, and yet it was the most negative news that surfaced first...
Hi Steve, difficult to understand this side of the world if this is more than a bit stoked up by political stance from EU cos we have left and this attitude will pervail for some time. Strange also they are downing the Astra vaccine as I heard that the EU actually raided some of Astra sites to take some for themselves as they seem to have underestimated the amount they need - disgraceful behaviour!!
Do we know id any different groups are tested as normal for new vaccinations etc, it is a minefield isn't it? I agree with you entirely about the risks we as a group take however we do need some help by having the vaccinations as most of our immune systems are compromised. I am having my first tomorrow and hubby is refusing to have it (feel bit put out by that but he has his own choice I suppose). I am going entirely by the messages from my hematologist and he says go for any/either of the strains of vaccine as none are live.
I have my first vaccination tomorrow to an area I will have to travel to which is 17 miles from home and would normally get in trouble for doing that as not a "local" site in lockdown rules!!! Hey ho!
Yes, there may be some angst in the political fallout of Brexit, however, we here in Australia are able to produce our own version of the Astra Zeneca (AZ) vaccine. Unfortunately, that doesn't change the fact that it is a manufactured from another 'Viral vector' and in that sense remains a 'Live' Vaccine, in my view...
Apparently, our government largely made this decision based upon the financial purse strings, AZ is the least expensive of course...
If you do have a choice Jenny, I would be leaning towards the Pfizer jab myself, or Moderna if available...
Best wishes & I shall be interested to learn how you find the Post experience too... Stay in touch...
Do you have any scientific basis for calling the AZ vaccine “live”. I see you qualify this statement by saying that it is in your opinion. There is so much misinformation about vaccines out there and you are well known on this forum for steering us towards scientific articles and appearing to be very knowledgeable. I am therefore very disappointed that you are posting this piece of misinformation. The AZ vaccine is NOT a live vaccine. Our haematologists would certainly not be recommending it to us if it was liveJan
As I have mentioned previously, the AZ, Pfizer & Moderna vaccines have not been adequately tested on the Aged or Immune compromised people. I have provided the References to these claims previously also, along with the fact that I too am an affected individual, and one who likes to do some home work before doing anything that might jeopardise my own longevity...
Taking Ruxolitinib simply means that I have a Suppressed Immune system... Which in turn means that I am far more vulnerable to infection than some others... Hence, my precautionary approach to vaccines, and especially those that are still untested.
In the end Jan, we must all make our own decisions about what we feel is best for each of us...
Not all of us have the same MPN, and or manage our conditions with the same treatments...
Best wishes
Steve
"What is the Astra Zeneca Vaccine?
Researchers at the University of Oxford built the vaccine using a kind of virus, called an adenovirus, that typically causes colds in chimpanzees. They genetically altered the virus so that it carried a gene for a coronavirus protein, which would theoretically train a person’s immune system to recognize the real coronavirus.
Adenovirus-based vaccines are also being tested by Johnson & Johnson, as well as by labs in China, Italy and elsewhere. An adenovirus-based vaccine called Sputnik V is already being distributed in Russia on an emergency basis, although researchers have yet to release detailed results from their late-stage trial.
Scientists have been testing adenovirus-based vaccines for decades, but it wasn’t until July of this year that the first one was licensed, when Johnson & Johnson got approval from European regulators for an Ebola vaccine."
"Is the AstraZeneca vaccine safe?
For years, Oxford researchers have been testing their chimpanzee adenovirus vaccine, ChAdOx1, on a number of other diseases including Ebola and Zika. Although none of those studies have reached the final, so-called Phase 3 trials, they have allowed researchers to examine the safety of the vaccine platform. The researchers have not found any serious side effects.
When the researchers adapted ChAdOx1 for Covid-19, their early clinical trials also did not turn up any adverse reactions. "
"In Phase 3 trials, however, the testing had to be paused twice when volunteers experienced neurological problems. The Food and Drug Administration did not directly tie the vaccine to the problems, but when the agency allowed the trial to resume in the United States, it advised the company to be vigilant for any signs of similar problems.
In their announcement on Monday, AstraZeneca and Oxford said that no serious safety issues were confirmed related to the vaccine."
DNA Inside an Adenovirus
The researchers added the gene for the coronavirus spike protein to another virus called an adenovirus.
Adenoviruses are common viruses that typically cause colds or flu-like symptoms.
The Oxford-AstraZeneca team used a modified version of a chimpanzee adenovirus, known as ChAdOx1. It can enter cells, but it can’t replicate inside them.
REFERENCE URL
How the Oxford-AstraZeneca Vaccine Works
By Jonathan Corum and Carl ZimmerUpdated Jan. 8, 2021
Hi Steve. I can take no issue with the fact that there is insufficient research into the affects of the vaccine in immunocomprised people. I assume problems will show up as the vaccine rollout continues across the world. I completely respect your decision not to have the vaccine in light of the research you have done. I very much welcome the knowledge you share with us all on this forum and usually think to myself “Steve has posted this so it must be of interest”. I too have advanced MF and taking Ruxolitinib and a white cell count that hovers around 2 if I’m lucky. I do not expect to get an optimum response from vaccination but I’m hoping that the people around me will and thus protect me to some degree. Having lived with being very neutropenic for a long time I am careful who I mix with and am no stranger to distance and hand sanitizer! I’m not so keen on the masks but know they make perfect sense!
My only issue with what you were saying is that the AV vaccine is live when it clearly isn’t. The current vaccine for shingles is live and I can’t have it BUT the shingrix vaccine for shingles is not live so is appropriate for people in yours and my situation. The AV vaccine is appropriate but may throw up problems in patients such as us as it is more widely used. Therefore we have to make our own decisions as to the risk of the vaccine compared to the risk of covid disease itself. Medicine today is always a matter of risk management and until medications are rolled out after stage 3 trials some affects don’t come to light which is where we are right now with all the covid vaccines
I’m just putting another point of view and by no means am I trying to provoke an argument. As I have stated I have a lot of respect for you and your knowledge and your attempts to share your knowledge here are very welcome
I don't think distance can be all that relevant. If you live in a town, you probably wouldn't have to travel so far. I live in a rural area and had to drive 15 miles for my Pfizer to a small ancient town - a very dark drive with snow and missing the turning the satnav gave because you just couldn't see it. We don't get in trouble driving because wherever you go it's not "local"!
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Astrazeneca vaccine and platelet rise
First PFIZER VACCINE DONE!
Transplant at age 68 or not
