Some of you might recall that sometime back I made mention of some results suggesting that different Blood Groups, (ABO), might in fact determine how someone might contract a mild case of CV–19 while others quite the opposite...
The article below theoretically describes why that might be so... And suggests that it could well be associated with the level of VWF present in an individuals system (?)
Many people w/ an MPN suffer from ET and too many Platelets, that fact and the use of of a blood thinner, namely aspirin, might indeed be a part of the larger picture behind the way the CV–19 affects people differently...
Hope that all makes sense, if not feel free to raise questions, I may not have all the answers, however, I will do my best to explain...
Stay safe & well
Steve
JULY 6, 2020
Complications from COVID-19 may depend on von Willebrand factor in the blood
Your knowledge amazes me Steve.....I have had P V Jak 2 for nearly 12 yrs,
Had all kinds of odd things with the blood ,Blasts etc,several emergency trips to my hospital and consultant of all my time of PV. Now on Rux ,H C T refuses to budge from 50 .....I carry on regardless until I have to admit defeat every day! I work as sculptor,have horses ,dogs,and the work that goes with them.I have lived longer than my consultant said he could keep me alive!!!
Apart from Forums in U K I have attended and advice on this site ,that is the extent of my knowledge....my French medics always have a different take on things anyway.I just had to answer you.....is it really better to know more?I am sure it is,being an artist and always living on lonely farms,the world in reality does not belong to hubby and me.Thanks tho I read every word you write. Keep well,keep going. Very Best Wishes,Sally.
Actually Steve ,I am unable to get 'chat' at all.I do usually use it for a 'friend',no luck tho....I wonder if anyone else is having the same prob,or has the format changed.....I am a bit useless with I. T.
Been a bit pre occupied have not noticed any changes on site.
Keep safe there in Oz !My daughter was in your country for several yrs loved it...France is enough for me!Sally
We are South West,between Bordeaux &Toulouse,fabulous countryside,Bastide villages & small towns.
Every one cycles,bunches of Lycra clad guys on the roads nearby.!
Did have the T de Fr very close some yrs ago.
Suddenly we have early tourists & people back to 'maison secondaires',thanks to Covid & no school in U K. Lots of Dutch on their cycles too.....it's a paradise for pedal power! We are a 'green area',been free from Covid since the start,tho still strict rules to be out and about . Best,Sally
Interesting article and it makes sense. My own von WB factors range from the normal range to a bit below norm. Not low enough to be Acquired vWBD, but low none-the-less. When I was on aspirin, I did have excessive bleeding and bruising. Prothrombin times were always outside the normal range a bit on the long side.
Interestingly, my platelets were up to 903 last week for no apparent reason. One of the highest reads I have ever had. Also pushed my aPTT to 36.8 - just outside the normal range. Bloody inconvenient time for that to happen right before the surgery! I would lay dollars to donuts that my vWBFs are low right now. Oh well, so it goes with MPNs. The docs are all over it so I am not worried about it.
There are a group of standard tests that can be done to make such determinations, but one also needs to recall what Blood Type they might be, (if indeed they are aware?)
According to this article, it suggests that of the Three (3) more common blood groups (ABO), people w/ A are more likely to be those w/ a higher level of VWF, and therefore potentially at greater risk. That does NOT imply however, that VWF cannot be high in other blood groups as well, just that it appears more likely that the greatest potential for higher VWF, is w/ those who might be of the A group.
If you are unsure of whether or not you are at greater risk of Von Willebrands Syndrome (VWS), the standard tests can easily be arranged via one's GP, and that should be all that is required to ascertain if one is VWS positive etc.
Finally, Smithy... please do not become overly alarmed by any of this, because it is all theoretical only at this point...
I know that I am VWS positive for (acquired?) Type 1 or 2? But I am still here too...
I say 'acquired' because some people w/ VWS gain it through hereditary, genetics etc. Whereas mine is thought to have been acquired through the progression of my MPN and its treatment regime etc.
However, and in my view. knowledge is power... For me, the more I know about my MPN, the more calm I feel about my outcomes... But that's just me...
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ET and Von Willibrands
CHANGE OF DATE for the webinar for MPN patients relating to government guidance on COVID-19
