A reason for MPN patients to have a more serious reaction to Covid19

[clubdino]

I have seen a lot of people questioning as to whether having a MPN makes us more at risk with Covid19. I just read a post on Twitter from a doctor who spoke about hypercoagulability and Covid19. It seems that Covid19 makes people more likely to clot. I will attach a screenshot of her statement. This isn't to scare anybody but only for us to know we must be extra cautious and if we do get Coronavirus we must immediately alert any doctor to the fact that we have a MPN.

[hunter5582]

I suspect where the risk lies may be in the cytokine storm associated with COVID 19. This would be a risk for everyone who contracts the virus. Risk of thrombosis, DVTs, pulmonary embolism would unfortunately make sense in the presence of a cytokine storm. For those of us with a MPN that is accompanied by elevated cytokine levels, we could theoretically be at increased risk. Whether premorbid elevated cytokine levels affects prognosis with COZID 19 is unknown.

From Lee et al - ASH COVID 19 Resources

"Published data have shown that the majority of patients with progressive, severe COVID-19 infection with acute lung injury/ARDS have very high D-dimer and fibrinogen levels, supportive of a hypercoagulable state from cytokine storm syndrome. "

hematology.org/covid-19/cov...

At this point, no one knows for sure how people with MPNs will react to contracting COVID 19. I would just as soon not become a part of that database.

All the best to all y'all. Stay safe and well.

[clubdino in reply to hunter5582]

They are also noticing a lot of them develop acute renal failure. Not sure if that is because of cytokine storm too. I saw a post where a lady said her husband was admitted to the hospital with a pulmonary embolism and covid at the same time. We still have a lot to learn about this virus.

[Scrollernut in reply to hunter5582]

Well I guess I was wrong. I haven’t seen your name pop up on my Facebook list since the first day. Can we try again?

[Dovme]

So many variables come into play

Obesity seems to be a huge concern now even without underlying health conditions

I have read various reports citing differences in infection and mortality due to gender, race and even blood type.

With doctors challenging each other’s hypothesis this has been particularly the case here in Germany

This morning l heard on the radio that some recoveries had no antibodies and uncertainties abt possible reinfection and the development of a vaccine for all with others saying it could be due to slow production of antibodies in some people

Lots of unknowns!

[clubdino in reply to Dovme]

The thought of reinfection is particularly scary.

[MarkD6701]

I take Warfarin and hopefully that should provide protection against any clots. I wonder if those who take low dose aspirin will have a bit of protection as well if they get the virus?

[Wyebird]

Thank you

[EleanorPV]

I look forward to seeing the data after this is all over.

[Dovme]

Interesting article yet again on the role of blood thinners : bccourier.com/a-swiss-resea...

This also seems to suggest to be proactive with doctors who may not know abt our conditions should we experience any symptoms.

[clubdino in reply to Dovme]

Very interesting. I didn't know that such a high amount were passing away at home. Now we understand why people kept reporting that covid patients were fine one moment and then very sick or gone the next minute.

[MaggieSylvie]

As I understand it, if you catch Covid19 you have a greater chance of blood clots because of proliferating platelets, making your blood sticky. That doesn't mean you will catch the virus more easily, especially if your immune system is good, which I think mine is (I take Rose Hips to boost it). But blood clots can lead to strokes and heart attacks. Just stay away from crowds!