Post by MPN-MATE Admin » Thu Dec 26, 2019 11:43 pm
Hey everyone...
Trusting that you have all enjoyed some happy times with family & friends over Christmas etc...
As many oy you might be aware, I am always scouring through research hoping to find that illusive 'Silver Bullet Cure' where perhaps no such things even exist... Sometimes, human research and Trials of the same, only lead to having created many other heretofore unknown or unrealised new sets of problems...
In very recent times, one such new notion involves the process of 'Gene Editing'...
Of the three (3) known 'Driver Mutations' thought to be the cause of MPNs, the CALR mutations are found in strands of human DNA through either a 'Deletion of exomes or an Insertion' along various parts of our human genome'
(The exome is composed of all of the exons within the genome, the sequences which, when transcribed, remain within the mature RNA after introns are removed by RNA splicing.)
CRISPR Cas9, which was co-invented by Drs Jennifer Doudna & Emmanuelle Charpentier. I shall endeavour to allow Jennifer to explain via these TED Talks:
Best wishes
Steve
(Sydney)
Written by
socrates_8
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Aneliv, it might be hard to help you understand this from writing... but I'm happy to try...
All the 'Driver Mutations (DMs)' thought to cause MPNs by changes to our human DNA via the chromosomes/exomes etc. Hence, essentially, the DMs are 'Editing the genome of our human DNA chains... Sorry but I cannot explain this any better...
The article I wrote about is for a new method that involves doing the same thing. One of the articles Referenced also discusses a Chinese creation of Twin girls that were designed by editing the human genome...
The technique mentioned in the article was created by two scientists, and they are warning and calling for a greater debate before humanity goes too far down that road of exploration...
CRSPR-Cas9, is the technique:
You can read more by going through the references yourself Aneliv...
Hope this helps
Steve
Cas9
An enzyme that geneticists are now using to help edit genes. It can cut through DNA, allowing it to fix broken genes, splice in new ones or disable certain genes. Cas9 is shepherded to the place it is supposed to make cuts by CRISPRs, a type of genetic guides. The Cas9 enzyme came from bacteria. When viruses invade a bacterium, this enzyme can chop up the germs DNA, making it harmless.
CRISPR
An abbreviation — pronounced crisper — for the term “clustered regularly interspaced short palindromic repeats.” These are pieces of RNA, an information-carrying molecule. They are copied from the genetic material of viruses that infect bacteria. When a bacterium encounters a virus that it was previously exposed to, it produces an RNA copy of the CRISPR that contains that virus’ genetic information. The RNA then guides an enzyme, called Cas9, to cut up the virus and make it harmless. Scientists are now building their own versions of CRISPR RNAs. These lab-made RNAs guide the enzyme to cut specific genes in other organisms. Scientists use them, like a genetic scissors, to edit — or alter — specific genes so that they can then study how the gene works, repair damage to broken genes, insert new genes or disable harmful ones.
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Hereditary MPNs -debunking some myths
Why do we have mutations?
ET & mild MF (negative for all gene mutations)
