Does anyone remember this info that has been shared a few times before.

Hi, I read a post I think from Maz some time ago , it was either info or an article which covered issues with different effects of MPN within the body ie raised adrenaline cholesterol etc, sorry to be so vague but I found the info really helpful but for the life of me can’t remember much more about it.. It was helpful in understanding some of the symptoms of my ET.

[Mazcd Partner MPNVoice]

Blimey Lindyloulou, you've got me there, even I can't remember it, sorry. Maz

[Kelly2 in reply to Mazcd]

[Hidden in reply to Mazcd]

Think the article also spoke about histamine levels. Thankyou for your response, I wish I could remember more, it has been shared more than once. Lynn

[Anag in reply to Hidden]

3 different hemos I had told me histamine problems have nothing to do with MPNs. The fourth said almost all his patients have this. The 5th said the same. As soon as I got on the AutoImmune Paleo diet, my histamine intolerance, which was plaguing me for 7 years (as long as I had ET), went away and I could take aspirin without feeling dizzy and having a tingling head and body and all that goes along with it. My cholesterol also got into the normal range within 6 mos. I eat 1-2 eggs daily! And no cholesterol. I believe the biggest culprit thing cholesterol has more to do with sugars and grains. We need cholesterol for our brains and the cells walls of every single cell in our body!!

There are different causes of rising cholesterol also. I will definitely try to find this article you mentioned! There’s probably new information for me! Thanks and all the best. Anag

[Hidden in reply to Anag]

Please see info below in reply to Maz.

Lynn

[Hidden in reply to Mazcd]

Hi there this was on another forum. Was not inflammation but metabolic abnormalities. Apologies for getting it wrong.

FOR OUR NEWER MEMBERS:

Save this for future reference.

[Recently, a new member asked me if the focus of our group

was MPD/Ns then why do I post articles relating to gout,

cholesterol, heartburn, acid reflux, peptic ulcers, diarrhea,

etc., etc. and to best explain I sent him a copy of these postings.

Too, we discuss other things because we are about the 'whole'

person because you are sooooooo much more than the fact

of your MPD/N. His response back to me was 'Wow, I had no idea!']

You may not realize that there are quite a few metabolic abnormalities that

can occur in MPD patients. About 50% will have, at some point, high uric acid

levels which is called hyperuricemia that can lead to joint pain and gout -- low

cholesterol level which is called hypocholesterolemia -- high histamine levels

happen in about 2/3 of MPD patients which can produce itching (pruritis), heart-

burn, acid reflux/belching, peptic ulcer, painful small bowel action which is called

hypermotility (diarrhea!), flushing, and allergic rashes. Hypermetabolism is most

commonly manifested as weakness and fatigue that occur in MPD patients not

having anemia...

Let me explain a bit further from a writing by a known expert, Dr. Harriet S.

Gilbert (now deceased after 50+ years in practice for MPDs) -- "Histamine and

related substances released by the basophils may also contribute to the higher

incidence of upper gastrointestinal (GI) problems, such as ulcers. Histamine is

known to stimulate the release of hydrochloric acid in the stomach. Histamine

may also produce diarrhea and increased bowel motility..."

[katiewalsh]

Hi. I’m afraid I don’t know but if you find it please let me know as I’m interested. Thanks. Katie

[EleanorPV]

As my cholesterol is rising (without my diet changing) I would be very interested in reading this article (if you ever come across it again).

[OZland]

This article describes how mpn affects different parts of your body

canadianmpnnetwork.ca/about...

[Hidden in reply to OZland]

Thankyou for your reply, not the same article but still very interesting. Lynn

[hunter5582]

Maybe this is the post you are thinking of. Note that the role of JAK2 signaling in increasing inflammatory cytokines can be quite significant.

JAK2 = Janus Kinase 2 gene. The JAK2 gene is comprised of a set of alleles. When some of these alleles become mutated, then you are JAK2+ - typically results in either ET or PV. The percentage of the alleles that are mutated = JAK2 Mutant Allele Burden. Speaking broadly, people with a JAK2 burden less than 50% will have a milder course of the MPN. There are a number of factors why this is so. JAK2 signaling drives hematopoiesis (thrombocytosis, leukocytosis, erythrocytosis). It is also thought to trigger thrombosis. Emerging research is focusing on the role JAK2 signaling play in increasing the production of inflammatory cytokines. The cytokines appear to be responsible for many of the secondary symptoms we all experience.

Here is one reference about the JAK2 Mutant Allele burden. bloodjournal.org/content/13....

Here is a reference to the role of inflammatory cytokines in MPNs ncbi.nlm.nih.gov/pmc/articl... .

There is a lot more out there on these topics. Takes a bit of effort to find the information - but knowledge is power and worth the effort. Hope this helps.

[Hidden]

Thankyou for taking the time to reply Lynn