Red blotches

[Hydrox]

Hi all, I have et jak 2+ for last 7 years no probs but have started getting roundish red blotches on my skin. Two under my arm, one the size of a 50p and the other a 5p. Today have found a large one one top if my thigh. I went to gp with the first two and they did not know what it was but gave me some steroid cream as they thought it might be a fungus. They asked when I was due back at the heamo clinic but said they would probably send me back to them to sort it. I was told to keep an eye on them and go back if they got worse, that was 3 weeks ago. Just wondering if anyone else has experienced these.

[hunter5582]

Hard to tell with this description. Pruritus is found with JAK2+, but usually with PV. Also does not sound like that anyway. JAK2 signaling system overactivation can increase production of inflammatory cytokines which theoretically could affect the skin. However, not all skin conditions are MPN related. If you are on any chemotherapy for the ET - maybe a reduced immune system could contribute?? I m JAK2+ PV and also get eczema. Might be JAK2 related, but no one really seems to know. Just saw a link to MPNs and granulomatous dermatitis - have no idea if anything like this is related to what you are experiencing. Since most docs know so little about MPNs, it is really hard to sort stuff like this out. Hope you get this sorted out soon. These skin conditions can really be aggravating and uncomfortable. All the best.

[Hydrox in reply to hunter5582]

Yes doc looked up side effects of hydroxy and said there are so many, it could be the meds going to ask the heamo nurse this am. Thanks for the reply.

[Miriammusic in reply to hunter5582]

Wow. I was very interested to read your post. In addition to the PV ( Jak2) and a host of other things, I also have granuloma annulare. I have never heard about any connection between the two and I had specifically asked my hemo. Can you please send me the link (if an actual link) or point me in the right direction as to the information? Thank you!!

[hunter5582 in reply to Miriammusic]

Here is the link re. granulomatous dermatitis ncbi.nlm.nih.gov/pubmed/267... . Don't know anything about this particular form of dermatitis. I do get atopic dermatitis (eczema).

Here is a link to study on role of inflammatory cytokines in MPN secondary symptoms.

hindawi.com/journals/mi/201...

There is a fair bit out there now on the link between MPNs and inflammatory cytokines. Lots of what we experience may in fact be related to these cytokines.

[Miriammusic in reply to hunter5582]

Thank you so much!!

[Hydrox in reply to hunter5582]

Thank you for the reply, very informative articles, although having to read several times for it to sink in lol. Maybe brain fog.

[hunter5582 in reply to Hydrox]

Me too on the several times + extra reading to understand all the terms and how it all relates. There is some really interesting findings out there around the role the cytokines play in MPNs. Looks promising in terms of helping us manage.

[BusyLizzie0030]

I have PV. I'm on hydroxycarbamide since 2011. I have started to get red blotches on lower arms occasionally. No itch from them but look inflamed. They look like infected insect bites but go away more quickly than bites. The fade and disappear.

[Hydrox in reply to BusyLizzie0030]

Yes my blotches do look like that but have no centre, I will ask heamo nurses advice today, thanks.