Hi younger MPN'ers,
I do not very often come across papers aimed at younger MPN patients so thought I would highlight this one that is being presented at the ASH conference in December. Nice to see that younger patients are being considered.
3033 Myeloproliferative Neoplasms in Young Patients: The Mayo Clinic Experience with 361 Cases Age 40 Years or Younger
A few quotes...
"Most available data, including current prognostic models, are excerpted from older populations and may not accurately mirror the unique phenotypic and prognostic patterns seen in younger patients."
"When appraised as a function of MPN subtype, survival data confirmed the significantly reduced OS in PMF relative to PV and ET (P<0.001), though PMF patients aged ≤ 40 years were still projected to have a reasonably favorable median life expectancy of 20 years "
"Young MPN patients comprise a unique disease subset defined by an attenuated-risk cytogenetic and mutational backdrop compared to their older counterparts. Caution must be exercised in counseling and managing this population as historical ‘one-size-fits all’ data fails to reflect the true natural history and disease biology in the young."
Great news though a word of caution from an oldie... It is still important that younger patients keep up their visits with their haematologists, know their particular circumstances/risks and look after themselves, just like us oldies.
Good reading and best wishes ...Simon